Biomimetic nanofibrous scaffolds for bone tissue engineering

By Jeremy M. Holzwarth, P. Ma. Biomaterials, 2011

632 citations recorded by the source corpus.

Bone tissue engineering is a highly interdisciplinary field that seeks to tackle the most challenging bone-related clinical issues. The major components of bone tissue engineering are the scaffold, cells, and growth factors. This review will focus on the scaffold and recent advancements in developing scaffolds that can mimic the natural extracellular matrix of bone. Specifically, these novel scaffolds mirror the nanofibrous collagen network that comprises the majority of the non-mineral portion of bone matrix. Using two main fabrication techniques, electrospinning and thermally-induced phase separation, and incorporating bone-like minerals, such as hydroxyapatite, composite nanofibrous scaffolds can improve cell adhesion, stem cell differentiation, and tissue formation. This review will cover the two main processing techniques and how they are being applied to fabricate scaffolds for bone tissue engineering. It will then cover how these scaffolds can enhance the osteogenic capabilities of a variety of cell types and survey the ability of the constructs to support the growth of clinically relevant bone tissue.

Subfields: Biomaterials, Biomedical Engineering, Surgery

View Paper: https://www.semanticscholar.org/paper/14a25818e340b988c9564ba2eb31bc3b18cca218

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Citations in the corpus

• Natural Polymeric Scaffolds in Bone Regeneration (2020, background): “Therefore, the search for suitable materials and innovative strategies to efficiently reproduce a bone microenvironment is constantly active (Stevens, 2008; Holzwarth and Ma, 2011), and novel formulations are developed and tested to improve their in vivo performance (Giannoudis et al.”