Balancing the activation state of the endothelium via two distinct TGF‐β type I receptors

By M. Goumans, Gudrun Valdimarsdottir, S. Itoh, Alexander Rosendahl, P. Sideras, P. ten Dijke. EMBO Journal, 2002

1,195 citations recorded by the source corpus.

Subfields: Immunology and Allergy, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/4bca8deec9b084dba0a0de9a3ca9604f960cf223

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology and Allergy

In Molecular Biology

Citations in the corpus

TGF-β signaling in fibrosis (2011, background): “In endothelial cells, TGF-b1 signals through a second type I TGF-b receptor, ALK-1 (Goumans et al. 2002).”
SPECIFICITY AND VERSATILITY IN TGF-β SIGNALING THROUGH SMADS (2005, background): “The nine-amino acid L45 loop, which connects β strands 4 and 5 in the kinase do- mains of the type I receptor, is accessible for protein interactions, as apparent from the structure of TβRI (Huse et al. 2001).”
Pericytes: developmental, physiological, and pathological perspectives, problems, and promises. (2011, background): “Two distinct type I TGFb receptors—activin receptor-like kinase (Alk)-1 and Alk-5—are expressed in both endothelial cells and mural cells and the two receptors appear to trigger different—even opposing—cellular effects (Goumans et al., 2002, 2003; Oh et al., 2000).”
TGFβ–SMAD signal transduction: molecular specificity and functional flexibility (2007, background): “Second, in endothelial cells, TGFβ can recruit both ALK5 and an endothelial-specific type I receptor, ALK1, into a single receptor complex, which results in the activation of both subsets of R-SMADs downstream of only one ligan”
Transforming growth factor–β in tissue fibrosis (2020, background): “In contrast, in other studies, partial loss of ALK1 enhanced fibroblast-mediated matrix synthesis (Muñoz-Félix et al., 2014b), and ALK1+/− mice”
Transforming Growth Factor (TGF)-β signaling in cardiac remodeling (2010, positive): “Apart from the well-characterized ALK5, which is expressed by many different cell types, endothelial cells express a second type I TGF-β receptor, termed ALK1 [12].”
A longitudinal study of angiogenic (placental growth factor) and anti-angiogenic (soluble endoglin and soluble vascular endothelial growth factor receptor-1) factors in normal pregnancy and patients destined to develop preeclampsia and deliver a small for gestational age neonate (2008, background): “Endoglin has been proposed to regulate the balance between these two opposite pathways [40].”
The role of TGF-β Signaling in Myocardial Infarction and Cardiac Remodeling (2007, background): “Apart from the well-characterized ALK5, which is expressed by many different cell types, endothelial cells express a second type I TGF-β receptor, termed ALK1 [ 10 ].”
Genetic Analysis of the Mammalian Transforming Growth Factor-β Superfamily (2002, background): “The activation state of each pathway is determined by the dose of TGF- present (203).”