Association of alcohol consumption with selected cardiovascular disease outcomes: a systematic review and meta-analysis
By P. Ronksley, S. Brien, B. Turner, K. Mukamal, W. Ghali. British medical journal, 2011
1,593 citations recorded by the source corpus.
Objective To conduct a comprehensive systematic review and meta-analysis of studies assessing the effect of alcohol consumption on multiple cardiovascular outcomes. Design Systematic review and meta-analysis. Data sources A search of Medline (1950 through September 2009) and Embase (1980 through September 2009) supplemented by manual searches of bibliographies and conference proceedings. Inclusion criteria Prospective cohort studies on the association between alcohol consumption and overall mortality from cardiovascular disease, incidence of and mortality from coronary heart disease, and incidence of and mortality from stroke. Studies reviewed Of 4235 studies reviewed for eligibility, quality, and data extraction, 84 were included in the final analysis. Results The pooled adjusted relative risks for alcohol drinkers relative to non-drinkers in random effects models for the outcomes of interest were 0.75 (95% confidence interval 0.70 to 0.80) for cardiovascular disease mortality (21 studies), 0.71 (0.66 to 0.77) for incident coronary heart disease (29 studies), 0.75 (0.68 to 0.81) for coronary heart disease mortality (31 studies), 0.98 (0.91 to 1.06) for incident stroke (17 studies), and 1.06 (0.91 to 1.23) for stroke mortality (10 studies). Dose-response analysis revealed that the lowest risk of coronary heart disease mortality occurred with 1–2 drinks a day, but for stroke mortality it occurred with ≤1 drink per day. Secondary analysis of mortality from all causes showed lower risk for drinkers compared with non-drinkers (relative risk 0.87 (0.83 to 0.92)). Conclusions Light to moderate alcohol consumption is associated with a reduced risk of multiple cardiovascular outcomes.
Subfields: Epidemiology, Neurology, Pathology and Forensic Medicine
View Paper: https://www.semanticscholar.org/paper/4bc0e235e52599534220cc5f913b5bbea27b90cd
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In Pathology and Forensic Medicine
Citations in the corpus
- Diet quality as assessed by the Healthy Eating Index, the Alternate Healthy Eating Index, the Dietary Approaches to Stop Hypertension score, and health outcomes: a systematic review and meta-analysis of cohort studies. (2015, background): “9 g/day (about 1 drink a day) was consistently associated with a 25% reduction in the risk of cardiovascular mortality, compared with abstaining from alcohol.(68) No significant risk reduction could be observed for neurodegenerative diseases.”
- 2016 European Guidelines on cardiovascular disease prevention in clinical practice (2017, neutral): “ciation appears not to be explained by special characteristics of abstainers [331], although the potential for residual confounding and reverse causality cannot be fully excluded.”
- Guidelines for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. (2014, background): “However, the risk of hemorrhagic stroke increases with any alcohol consumption, with greater risk with heavy use.(329,330) The protective effect of moderate alcohol consumption may be related to increased levels of HDL-C, apolipoprotein A1, and adiponectin, as well as lower levels of fibrinogen and ”
- Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013 (2015, neutral): “43,44 Recent studies confi rmed previous meta-analyses that indicated a protective eff ect of high BMI on breast cancer in premenopausal women outside Asia–Pacifi c countries.”
- Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity – A Comprehensive Review (2016, neutral): “5 drink per day for women – is associated with lower incidence of CHD and diabetes mellitus, although not stroke.(288,289) Such observational analyses could partly overestimate benefits, because never drinkers could include those who have avoided alcohol because of unmeasured factors that relate to ”
- Shared Risk Factors in Cardiovascular Disease and Cancer (2016, background): “Alcohol and CVD Moderate alcohol consumption has a well-established cardioprotective effect, although in the absence of any randomized, controlled data.(73) In patients with established cardiovascular disease, meta-analyzed data (8 observational studies) of 16 351 patients found moderate alcohol con”
- “The Mediterranean Diet, its Components, and Cardiovascular Disease” (2014, background): “Estimates of lifestyle modifications such as the Mediterranean diet as a whole (106), fruits and vegetables (59, 61, 62), smoking cessation (103), moderate alcohol (105), omega-3 fatty acids (110), and improved physical activity (102) have substantial benefits for CVD prevention not seen with common”
- Evidence-based policymaking: promise, challenges and opportunities for accounting and financial markets research** (2018, neutral): “Many studies as well as several meta-analyses suggest a J-shaped relation between alcohol consumption and mortality risk, indicating reduced risk for occasional and low-volume drinkers but higher risk for higher volume drinkers (e.g. Brien et al. 2011, Ronksley et al. 2011).”