YIA3: ADAMTS7 CLEAVAGE AND VASCULAR SMOOTH MUSCLE CELL MIGRATION IS AFFECTED BY A CORONARY ARTERY DISEASE ASSOCIATED VARIANT

By Xiangyuan Pu, Q. Xiao, S. Kiechl, K. Chan, F. Ng, Shivani Gor, R. Poston, Changcun Fang, A. Patel, E. C. Senver and 8 more. 2013

112 citations recorded by the source corpus.

Subfields: Molecular Biology

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In Molecular Biology

1. R. Khalil
2. S. Zhong
3. S. Apte

Citations in the corpus

• A Disintegrin and Metalloproteinase (ADAM) and ADAM with Thrombospondin Motifs (ADAMTS) Family in Vascular Biology and Disease (2019, background): “Therefore, the Pro variant may have lower activity and individuals with the Pro/Pro ADAMTS-7 protein could have reduced protease activity compared to those with Ser/Ser variants [124].”
• ADAMTS-7 Inhibits Re-endothelialization of Injured Arteries and Promotes Vascular Remodeling Through Cleavage of Thrombospondin-1 (2015, background): “VSMC migration, COMP cleavage, and the prevalence of atherosclerosis.(16) Moreover, ADAMTS-7 promotes VSMC”
• Association between plasma ADAMTS-7 levels and severity of disease in patients with stable obstructive coronary artery disease (2016, background): “Moreover, rs3825807G/G genotype in the ADAMTS-7 locus was associated with lower atherosclerosis prevalence and severity.([17]) However, the direct report of circulation ADAMTS-7 levels in stable CHD patients is still lacking.”
• Knockout of Adamts7, A Novel CAD Locus in Humans, Reduces Atherosclerosis in Mice (2015, result): “These rodent data are also in broad agreement with a recent report suggesting that a CAD-promoting coding variant in humans is associated with reduced ADAMTS7 protein secretion and function.(26) Our data strongly suggest that in mouse models of atherosclerosis and vascular injury, Adamts7 plays a ke”
• Biochemistry and physiological functions of ADAMTS7 metalloprotease (2013, background): “Both the mRNA and protein of ADAMTS7 were induced by the proinflammatory cytokines, tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), and by growth factor platelet derived growth factor (PDGF)-BB (Figure2) [23, 24].”
• ADAMTS proteins in human disorders (2018, background): “ADAMTS7 was co-localized with macrophages and smooth muscle cells in coronary and carotid atherosclerotic plaque with staining present throughout the plaque, including the shoulder, cap and core [77, 80].”