Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity.

By F. Guengerich. Chemical Research in Toxicology, 2001

1,604 citations recorded by the source corpus.

Subfields: Inorganic Chemistry, Oncology, Pharmacology

View Paper: https://www.semanticscholar.org/paper/4afb38feffcc8566bc246674ccc978b8d587556a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Inorganic Chemistry

1. A. Pfohl-leszkowicz
2. Gerard D. Wright
3. S. Hecht
4. R. Manderville

In Oncology

1. Magali Olivier
2. Pierre Hainaut
3. A. Pfohl-leszkowicz
4. Gerard D. Wright
5. S. Hecht
6. R. Manderville

In Pharmacology

1. A. Pfohl-leszkowicz
2. Gerard D. Wright
3. S. Hecht
4. R. Manderville

Citations in the corpus

• Ochratoxin A: An overview on toxicity and carcinogenicity in animals and humans. (2007, background): “[312] Guengerich, F.”
• Tobacco smoke carcinogens, DNA damage and p53 mutations in smoking-associated cancers (2002, background): “Cytochrome P450 enzymes catalyze addition of an oxygen atom to the carcinogen, increasing its water solubility and converting it to a form that is more readily excretable (Guengerich, 2001).”
• An overview of the main pathways of metabolic resistance in insects (2016, background): “They catalyse the transfer of one atom of molecular oxygen to a substrate and the reduction of the second atom of oxygen to form water; the process requires the transfer of two electrons provided by NADPH cytochrome P450 reductase (Feyereisen, 2005; Guengerich, 2008).”
• Tobacco carcinogens, their biomarkers and tobacco-induced cancer (2003, background): “Metabolic activation is generally initiated by cytochrome P450 enzymes (P450s), which are part of normal mammalian systems designed to respond to foreign compound”
• Bacterial resistance to antibiotics: enzymatic degradation and modification. (2005, background): “This molecular strategy occurs primarily through a cadre of membrane-bound cytochrome P-450s with broad substrate specificity that hydroxylate xenobiotics to facilitate their excretion [100].”
• iArc monogrAphs on the evAluAtion oF cArcinogenic risks to humAns (2012, background): “Electrophilic intermediates may react with water, generally resulting in detoxification, or may covalently bind to nucleophilic (elec­ tron rich) sites in DNA, forming DNA adducts (Guengerich, 2001; Jalas et al., 2005), which are critical in the carcinogenic process (see Section”