Necroptosis: the release of damage-associated molecular patterns and its physiological relevance.

By A. Kaczmarek, Peter Vandenabeele, D. Krysko. Immunity, 2013

1,362 citations recorded by the source corpus.

Subfields: Molecular Biology, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/4ad2ca0255e081ed91d244cfcf221cae499354b3

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In Nutrition and Dietetics

Citations in the corpus

Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications (2021, background): “The TNF family of cytokines can recruit activate caspase‐8 through the adaptor protein FADD, further triggering apoptosis; however, under certain conditions, suppression of caspase‐8 or FADD increases the sensitivity to these cytokines, causing necroptosis.(86,87) Necroptosis is regulated necrotic c”
Global Survey of Cell Death Mechanisms Reveals Metabolic Regulation of Ferroptosis (2016, methodology): “FIN56 Target Identification Conjugation of active and inactive probes with Profinity Epoxide Resin—6 μmol of Active (SRS11-31) or inactive (SRS11-66) probes dissolved in 500 μL DMSO and 300mg of Profinity™ Epoxide Resin (Bio-Rad) were incubated in saturated sodium bicarbonate at 45 °C for 3 days.”
The Development of the Concept of Ferroptosis (2018, neutral): “normal physiological functions, such as the modulation of inflammation and the maintenance of adult T-cell homeostasis [15,21,22], and may”
Inflammation and aging: signaling pathways and intervention therapies (2023, background): “However, necroptosis triggers inflammation through the massive release of DAMPs from the disintegrating cell.(237) Fig.”
To be or not to be? How selective autophagy and cell death govern cell fate. (2014, positive): “Under conditions in which TNFR1 is engaged but caspase-8-FLIP activity is blocked or disrupted, the RIPK3-MLKL interaction is promoted to cause necrotic cell death (Kaczmarek et al., 2013) through an effector mechanism that remains elusive but is likely to involve the plasma membrane.”
Necroptosis: a regulated inflammatory mode of cell death (2018, background): “Numerous in vitro studies have reported that inhibition of caspase-8 molecules resulted in activation of RIPK3, a key player of necroptosis [6, 7, 23].”