Batf3 Deficiency Reveals a Critical Role for CD8α+ Dendritic Cells in Cytotoxic T Cell Immunity

By K. Hildner, B. Edelson, Whitney E. Purtha, Mark S. Diamond, H. Matsushita, M. Kohyama, B. Calderon, Barbara U. Schraml, E. Unanue, Michael S. Diamond and 3 more. Science, 2008

2,009 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/4a9efbbdfe089aef6c2e78e21422386e3a0b7c66

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Florent Ginhoux
2. Miriam Merad
3. O. Joffre
4. T. Gajewski
5. Hugo Gonzalez
6. F. Quintana
7. E. Stanley
8. Erik Sahai

In Molecular Biology

1. Hugo Gonzalez
2. Paul Robson
3. Andrea Califano
4. E. Stanley
5. Erik Sahai
6. T. Gajewski
7. K. Murphy
8. Giulia Biffi

Citations in the corpus

• Expansion and activation of CD103+ dendritic cell progenitors at the tumor site enhances tumor responses to therapeutic PD-L1 and BRAF inhibition (2016, neutral): “These results are also in accordance with prior studies showing the requirement for CD103+ DCs in the induction of therapeutic immunity against fibrosarcoma tumor grafts (Hildner et al., 2008).”
• Successful anti-PD-1 cancer immunotherapy requires T cell-dendritic cell crosstalk involving the cytokines IFN-γ and IL-12 (2018, neutral): “Both DC1s and DC2s expressed the DC markers Batf3, Flt3, H2-Dmb2, and Zbtb46 (Meredith et al., 2012; Hildner et al., 2008); DC1s expressed Fscn1 and Ly75 (DEC-205); and DC2s expressed CD209a (DC-SIGN),Mgl2 (CD301b), and Cd24a (Figures 2B and S2B).”
• Tolerogenic dendritic cells (2016, background): “CD8α cDCs efficiently present exogenous antigens to CD8 T cells; these cells also require Id2 and the basic leucine zipper transcription factor, ATF-like 3 (Batf3) for their differentiation [25, 26], but a Batf3-independent pathway has also been described for their generation [27].”
• Characterization of human DNGR-1+ BDCA3+ leukocytes as putative equivalents of mouse CD8α+ dendritic cells (2010, background): “Notably, CD8+ DCs, but not other DC subtypes have recently been shown to depend on the transcription factor Batf3 for their development, suggesting that they represent an ontogenetically distinct mouse leukocyte lineage (Hildner et al., 2008).”
• Development and function of dendritic cell subsets. (2014, neutral): “Generation of CD103 cDCs accordingly depends on IRF8, ID2, and BATF3 (Ginhoux et al., 2009; Hildner et al., 2008).”
• NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control (2018, background): “…demonstrating that the lack of cDC1 in Batf3 / mice abolishes the rejection of immunogenic tumors and the response to adoptive T cell therapy and to immune checkpoint blockade (Broz et al., 2014; Hildner et al., 2008; Salmon et al., 2016; Sánchez-Paulete et al., 2016; Spranger et al., 2015).”