Mediating tumor targeting efficiency of nanoparticles through design.

By S. Perrault, C. Walkey, T. Jennings, H. Fischer, W. Chan. Nano letters (Print), 2009

1,435 citations recorded by the source corpus.

Subfields: Biomaterials, Biomedical Engineering, Electronic, Optical and Magnetic Materials

View Paper: https://www.semanticscholar.org/paper/4a9450a12b71ef4b4ccc0a84559ba78683d06a76

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biomaterials

1. O. Farokhzad
2. N. Bertrand
3. N. Kamaly
4. Xiaoyang Xu
5. Jun Wu
6. Alexandre Albanese
7. J. Hanes
8. Horacio Cabral

In Biomedical Engineering

1. N. Bertrand
2. Xiaoyang Xu
3. N. Kamaly
4. Jun Wu
5. Mark E. Davis
6. O. Farokhzad
7. W. Chan
8. R. Singh

In Electronic, Optical and Magnetic Materials

1. Alexandre Albanese
2. P. S. Tang
3. O. Farokhzad
4. N. Bertrand
5. G. Ulrich Nienhaus
6. Edward A. Sykes
7. Wolfgang J. Parak
8. G. Zheng

Citations in the corpus

• Surface Functionalization of Nanoparticles with Polyethylene Glycol: Effects on Protein Adsorption and Cellular Uptake. (2015, result): “In agreement with previous studies, we have observed that PEGylation reduces NP uptake by cultured cells.(5,6,8,9,11,14,15,17) Whereas proteins were adsorbed onto the outer surface of the non-PEGylated NPs, proteins likely reside inside the PEG layer for PEGylated NPs.”
• Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size. (2011, background): “), nanomedicines in the sub-100 nm range are now regarded as being more important in the study of tumour penetratio”
• Investigating the impact of nanoparticle size on active and passive tumor targeting efficiency. (2014, background): “Similar to previous work, both size and surface chemistry affected tumor penetration.(16,34) Small passively targeted AuNPs diffused further into the tumor microenvironment than larger sizes (Figure 5), Figure 4.”
• Factors controlling the pharmacokinetics, biodistribution and intratumoral penetration of nanoparticles. (2013, background): “Regardless of the mechanism by which PEG works and how well it improves PK and BD, significant RES clearance is still an issue, with typically >50% of the injected dose (ID) ending up in the liver and spleen after 48 h even for highly optimized PEGylated particles [13, 14, 26, 27].”
• Mechanism of active targeting in solid tumors with transferrin-containing gold nanoparticles (2009, background): “(10) convincingly illustrated that PEGylated gold nanoparticles (AuNPs) must be <100 nm in diameter to move away from the vasculature and throughout the tumor.”
• Gold nanoparticle-mediated photothermal therapy: applications and opportunities for multimodal cancer treatment (2017, background): “compared the tumor penetrating abilities of 20 nm, 60 nm, and 100 nm solid gold spheres and found that larger size limits the distance NPs can travel away from blood vessels and into tumors.(26) However, tumor retention of smaller AuNPs is challenging because they are rapidly cleared from the extrac”