Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size.

By Horacio Cabral, Yu Matsumoto, K. Mizuno, Qixian Chen, M. Murakami, M. Kimura, Y. Terada, M. Kano, K. Miyazono, M. Uesaka and 2 more. Nature Nanotechnology, 2011

2,219 citations recorded by the source corpus.

Subfields: Biomaterials, Biomedical Engineering, Genetics

View Paper: https://www.semanticscholar.org/paper/59c4efe551696108e2754c95b1cdae4c2a351484

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In Biomaterials

1. Shuming Nie
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In Biomedical Engineering

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Citations in the corpus

• Size-Dependent Localization and Penetration of Ultrasmall Gold Nanoparticles in Cancer Cells, Multicellular Spheroids, and Tumors in Vivo (2012, neutral): “When drug-loaded polymeric micelles with diameters of 30, 50, 70, and 100 nm were tested for their antitumor effect in mice, only the 30 nm polymer micelles were found to penetrate pancreatic tumors.(8) Recently, a smart nanoparticle composed of quantum dots realized both the long circulation half-l”
• Advanced Materials and Processing for Drug Delivery: The Past and the Future (2012, background): “In a study of accumulation of long-circulating polymeric micelles at tumor site, Kataoka and colleagues show only those smaller than 30 nm could effectively penetrate poorly permeable pancreatic tumors [7].”
• Stimuli-responsive clustered nanoparticles for improved tumor penetration and therapeutic efficacy (2016, background): “This is particularly important for treating poorly permeable solid tumors, because only the sub–30-nm micelles could penetrate the poorly permeable pancreatic tumors to achieve an antitumor effect (27).”
• Factors controlling the pharmacokinetics, biodistribution and intratumoral penetration of nanoparticles. (2013, background): “Once particles successfully extravasate into the tumor compartment, the particles must travel through the stroma against high interstitial fluid pressure (IFP) gradients, and ultimately interact with the target cells or release the drug payload for pharmacological effect.”