Mechanism of active targeting in solid tumors with transferrin-containing gold nanoparticles

By C. H. J. Choi, Christopher A. Alabi, P. Webster, Mark E. Davis. Proceedings of the National Academy of Sciences of the United States of America, 2009

675 citations recorded by the source corpus.

Subfields: Biomaterials, Electronic, Optical and Magnetic Materials, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/89a03f74ca8fad5584343f168356a7999797eb49

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Citations in the corpus

Drug targeting to tumors: principles, pitfalls and (pre-) clinical progress. (2012, result): “Similar findings have been reported by Davis and colleagues, who showed that overall, transferrin-targeted nanoparticles did not accumulate in tumors to a higher extent than did untargeted nanoparticles, but that they did improve the uptake of the particles by cancer cells in tumors [61].”
Insight into nanoparticle cellular uptake and intracellular targeting (2014, positive): “reported that PEGylated gold nanoparticles with different amounts of human transferrin for active targeting leading to an efficient nanoparticle internalization into TfR over expressing cancer cells (Neuro2A cells) as well as in the tumor site in Neuro2A tumor-bearing mice, suggesting greater intrac”
Progress in tumor-associated macrophage (TAM)-targeted therapeutics (2017, neutral): “Although many drug delivery systems targeting transferrin receptor have been reported, to our knowledge, all these systems are tailored toward targeting cancer cells expressing the receptor or enhancing transcytosis across blood brain barrier, and neither the effect on nor the application to affect ”
Investigating the impact of nanoparticle size on active and passive tumor targeting efficiency. (2014, background): “as their reported cell dissociation constants were above our proposed cutoff range.(6)”
Functionalized Gold Nanoparticles and Their Biomedical Applications (2011, background): “Studies have been conducted on nanoparticles functionalized with fluorophores, peptides, cell adhesion molecules, aptamers or other biomolecules to target specific tissues and thereby holding promise to be used for imaging of tumors, drug delivery and detection of apoptosis [28,55,92,98] (Figure 4).”
Tumor Targeting via EPR: Strategies to Enhance Patient Responses (2018, background): “This is in line with the finding that the overall tumor accumulation of a nanomedicine formulation generally does not improve upon active targeting, while its intratumoral distribution may benefit, as a result of more target cell uptake and less macrophage uptake [216,217].”