Regulation of Neurotransmitter Release by Metabotropic Glutamate Receptors

By J. Cartmell, D. Schoepp. Journal of Neurochemistry, 2000

913 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/49f62bb56551f709df51c0fd97ae35bfe04aff6e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. Peter W. Kalivas
2. D. Holtzman
3. D. Schoepp
4. Nora D. Volkow
5. R. Malenka
6. Kent C. Berridge
7. G. Koob

In Molecular Biology

1. Peter W. Kalivas
2. D. Schoepp
3. D. Holtzman

Citations in the corpus

• Metabotropic glutamate receptors as novel targets for anxiety and stress disorders (2005, background): “The mGlu 2 receptors are generally expressed at extrasynaptic sites on neuronal terminals, where they have been shown to suppress excitatory amino-acid neurotransmission at a number of synapse”
• Ionotropic and metabotropic glutamate receptor structure and pharmacology (2005, neutral): “…presynaptic, localised in axonal domains and axon terminals where they can regulate neurotransmitter release (Shigemoto and Mizuno 2000; Cartmell and Schoepp 2000). mGluRs are members of the wider G-protein-coupled receptor (GPCR) family Cwhich also includes the GABAB, pheromone, and…”
• N-Acetylaspartate in the CNS: from neurodiagnostics to neurobiology. (2007, background): “Metabotropic glutamate receptors are involved in regulating neurotransmitter release, including the release of glutamate (Cartmell and Schoepp, 2000), and disorders of the NMDA type of glutamate receptor have been strongly implicated in the etiology of schizophrenia (Moghaddam and Jackson, 2003).”
• Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system. (2001, neutral): “Indeed, electrophysiological and biochemical studies have shown that mGlu2/3 receptor agonists and the group-III-selective agonist L-AP4 will suppress the release of GABA from neurons (see Anwyl, 1999; Cartmell and Schoepp, 2000).”
• The Origin and Neuronal Function of In Vivo Nonsynaptic Glutamate (2002, background): “The role of PKA in the inhibition of cystine–glutamate exchange by APDC was examined because mGluR2/3 is G i -coupled and inhibits PKA activity (Cartmell and Schoepp, 2000), as well as the fact that the sequence of human Xct contains two consensus PKA phosphorylation sites (revealed in a search for…”
• Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo. (2005, background): “When activated, mGluR2/3 decreases glutamate release into the dentate granule cell neurons (Cartmell and Schoepp, 2000), thereby decreasing neuronal activation.”