The molecular mechanics of eukaryotic translation.

By Lee D Kapp, J. Lorsch. Annual Review of Biochemistry, 2003

606 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/499f4c351f1f03f9c7285f1078a7f9682af24ace

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Citations in the corpus

The eukaryotic translation initiation factors eIF1 and eIF1A induce an open conformation of the 40S ribosome. (2007, background): “In eukaryotes, at least 12 initiation factors (eIFs), composed of $28 polypeptides , are involved in this process, whereas only three factors are required in prokaryotes (Kapp and Lorsch, 2004b).”
Regulation of translation via mRNA structure in prokaryotes and eukaryotes. (2005, background): “All rights reserved. doi:10.1016/j.gene.2005.06.037 functions of these proteins (Dever, 2002; Kapp and Lorsch, 2004; Laursen et al., 2005; von der Haar et al., 2004).”
Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? (2008, background): “Interaction of eIF4G with another initiation factor, eIF3, facilitates the recruitment of the 40S ribosomal subuni”
Inhibition of Eukaryotic Translation Elongation by Cycloheximide and Lactimidomycin (2010, background): “Normal cap-dependent initiation requires the concerted action of at least 12 initiation factors, which tightly regulate assembly of mRNA and initiator tRNA on the small ribosomal subunit before allowing the joining of 40S and 60S subunit”
Synthetic Messenger RNA as a Tool for Gene Therapy (2006, positive): “The mRNA 3 (cid:4) poly(A) tail stimulates translation initiation both in vitro and ex vivo (Brawerman, 1981; Tarun and Sachs, 1995; Kapp and Lorsch, 2004).”
Studies on the role of helix 69 of 23S rRNA in the factor-dependent stages of translation initiation, elongation, and termination (2011, background): “…is a process of astounding intricacy that is catalyzed by more than ten protein factors, including helicases, GTPases and RNA-binding proteins (Kapp and Lorsch 2004; Sonenberg and Hinnebusch 2009; Myasnikov et al. 2009), it is considerably simpler in bacteria where only three initiation…”
Control of translation and mRNA degradation by miRNAs and siRNAs. (2006, background): “The process of translation initiation occurs by a series of key steps (for review, see Kapp and Lorsch 2004).”
Molecular architecture of a eukaryotic translational initiation complex (2013, methodology): “Yeast tRNAi Met purification was purified as described (30) withminormodifications: After phenol extraction of cell lysate, the aqueous phase was ethanol precipitated and the resuspended pellet”
Large-scale mapping of human protein–protein interactions by mass spectrometry (2007, background): “Translation initiation and elongation factors The molecular mechanisms underlying protein synthesis in eukaryotic organisms are complex and only partially understood (Kapp and Lorsch, 2004).”