Transcription Start Regions in the Human Genome Are Favored Targets for MLV Integration

By Xiaolin Wu, Yuan Li, B. Crise, S. Burgess. Science, 2003

1,394 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Virology

View Paper: https://www.semanticscholar.org/paper/499d38c3ecca0a367f085da501b63307b28575ff

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

In Molecular Biology

Citations in the corpus

Towards safe, non-viral therapeutic gene expression in humans (2005, background): “However, it has recently become obvious that both MLV and lentivirus preferentially integrate into transcriptionally active regions of the genom”
Retroviral DNA Integration: ASLV, HIV, and MLV Show Distinct Target Site Preferences (2004, methodology): “A previous study revealed that integration by MLV is favored near transcription start sites, but no such bias was seen for HIV (Wu et al. 2003).”
A transposon-mediated gene trap approach identifies developmentally regulated genes in zebrafish. (2004, methodology): “Linearized pBluescript (Stratagene) DNA was used as the backbone plasmid probe.proviral insertions (Golling et al., 2002), although the retrovirus preferentially integrates in the transcription start region of genes (Wu et al., 2003).”
A Mammalian enhancer trap resource for discovering and manipulating neuronal cell types (2016, methodology): “Amplification of insertion sites by ligation mediated (LM)-PCR was performed as described by Wu et al. (Wu et al., 2003).”
Integrase inhibitors to treat HIV/Aids (2005, background): “, whereas murine leukaemia virus (MLV) integrates preferentially in transcription start region”
Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1. (2008, background): “A duplication at 6q22-23 was also detected in P4 (Figure 6C), consistent with the unbalanced translocation t(6;13) that was previously reported (5).”