Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration.
By Takehiko Sasaki, J. Irie-Sasaki, Russell G. Jones, A. Oliveira-dos-Santos, W. Stanford, B. Bolon, A. Wakeham, A. Itié, D. Bouchard, I. Kozieradzki and 5 more. Science, 2000
1,158 citations recorded by the source corpus.
Subfields: Cancer Research, Genetics, Immunology and Allergy
View Paper: https://www.semanticscholar.org/paper/4973beedd0502e6db453f3066abc01ec4a75b86d
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Citations in the corpus
- Targeting the phosphoinositide 3-kinase (PI3K) pathway in cancer (2009, background): “p110γ is mainly expressed in leukocytes but is also found in the heart, pancreas, liver and skeletal muscl”
- Phosphoinositides: tiny lipids with giant impact on cell regulation. (2013, background): “These include a specific role of the kinase in platelet aggregation in response to Gi-coupled receptors, such as the ADP-receptor P2Y12 (623, 907), or in T-cell signaling (1346) and T-cell development resulting in a decreased CD4 /CD8 T-cell differentiation ratio in PI3K deficient mice (1279, 1346).”
- International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the Formyl Peptide Receptor (FPR) Family (2009, background): “The PI3K family of lipid kinases has been found to play important roles in signaling for chemotaxis downstream of chemoattractant receptors (Niggli and Keller, 1997; Hirsch et al., 2000; Li et al., 2000; Sasaki et al., 2000).”
- Proliferation, survival and metabolism: the role of PI3K/AKT/mTOR signalling in pluripotency and cell fate determination (2016, background): “…but with defects in lymphocyte development (Ciraolo et al., 2008) p110γ−/− Develop normally but with impaired thymocyte development and T-cell activation (Sasaki et al., 2000) p85a-p55a-p50a−/−* Perinatal lethality; extensive hepatocyte necrosis (Fruman et al., 2000) p85a−/− Hypoglycaemia;…”
- PI3K in lymphocyte development, differentiation and activation (2003, methodology): “Mice deficient for p110γ have been reported by three group”