REM Sleep Reorganizes Hippocampal Excitability

By Andres D. Grosmark, Kenji Mizuseki, E. Pastalkova, Kamran Diba, György Buzsáki. 2012

315 citations recorded by the source corpus.

SUMMARY Sleep is composed of an alternating sequence of REM and non-REM episodes, but their respective roles are not known. We found that the overall firing rates of hippocampal CA1 neurons decreased across sleep concurrent with an increase in the recruitment of neuronal spiking to brief “ripple” episodes, resulting in a net increase in neural synchrony. Unexpectedly, within non-REM episodes, overall firing rates gradually increased together with a decrease in the recruitment of spiking to ripples. The rate increase within non-REM episodes was counteracted by a larger and more rapid decrease of discharge frequency within the interleaved REM episodes. Both the decrease in firing rates and the increase in synchrony during the course of sleep were correlated with the power of theta activity during REM episodes. These findings assign a prominent role of REM sleep in sleep-related neuronal plasticity.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Experimental and Cognitive Psychology

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Citations in the corpus

Replay in Deep Learning: Current Approaches and Missing Biological Elements (2021, neutral): “The decline of replay in recent experiences during sleep is followed by the resetting of hippocampal excitability during REM sleep (Grosmark, Mizuseki, Pastalkova, Diba, & Buzsáki, 2012), which may allow the hippocampus to encode new memories.”
Sleep and the Price of Plasticity: From Synaptic and Cellular Homeostasis to Memory Consolidation and Integration (2014, background): “In a recent study (Grosmark et al., 2012), firing rates of hippocampal CA1 neurons decreased across sleep, as they do in cortex (Vyazovskiy et al., 2009) but did so in REM sleep as a function of REM theta power and not, as they do in cortex, in NREM sleep as a function of SWA (Vyazovskiy et al.,…”
Plasticity during Sleep Is Linked to Specific Regulation of Cortical Circuit Activity (2017, background): “On average, hippocampal principal cells increased firing activity in the course of a single SWS episode (Grosmark et al., 2012).”
What is normal in normal aging? Effects of Aging, Amyloid and Alzheimer’s Disease on the Cerebral Cortex and the Hippocampus (2014, background): “…Tamnes et al., 2012), are highly vulnerable to aging has lead to the hypothesis of an anterior-toposterior gradient of age vulnerability, which has been invoked to explain the decline in executive function often observed in healthy elderly samples (Gunning-Dixon and Raz, 2003; Head et al., 2009).”
Sleep Is for Forgetting (2017, result): “Indeed, Buzsáki’s group (Grosmark et al., 2012) showed that hippocampal firing rates increase across SWS and decrease across REM sleep, a result more consistent with depotentiation occurring in REM sleep.”