ERK implication in cell cycle regulation.

By J. Chambard, R. Lefloch, J. Pouysségur, P. Lenormand. Biochimica et Biophysica Acta, 2007

784 citations recorded by the source corpus.

Subfields: Molecular Biology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/493ab5c531b71f7b1b6fcd1f9610753da0c98f51

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In Molecular Biology

1. J. Mouw
2. Michael W. Pickup
3. Ping Wee
4. Valerie M. Weaver
5. Zhixiang Wang
6. Kevin W. Eliceiri
7. David Inman
8. P. Keely

In Pathology and Forensic Medicine

1. Ping Wee
2. Zhixiang Wang

Citations in the corpus

• Matrix density-induced mechanoregulation of breast cell phenotype, signaling, and gene expression through a FAK-ERK linkage (2009, positive): “In addition, ERK is predicted to regulate TFs associated with earlier phases of the cell cycle (such as E2F, c-Myb, Elk-1; (Chambard et al., 2007;Oh & Reddy, 1999)), consistent with our finding that ERK inhibition resulted in reduced expression of genes associated with each phase of the cell cycle…”
• The extracellular matrix modulates the hallmarks of cancer (2014, positive): “Indeed, in response to a stiffened matrix, cells elevate Fak phosphorylation and stimulate Erk, PI3K and Rac, which accelerates cell cycle progression through increased expression of cyclin D1 [7,32–34].”
• Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways (2017, background): “Importantly, the activated ERK MAPK and AKT pathways also inhibit various pro-apoptotic proteins, including BIM, Caspase-9, and BAD.”