Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis.

By S. Basu, N. Totty, M. Irwin, M. Sudol, Julian Downward. Molecules and Cells, 2003

848 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/48fe5b7f2cf07f58c158902bfb9ec8dd6257da93

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In Cell Biology

1. K. Guan
2. Bin Zhao
3. Duojia Pan
4. G. Halder
5. Xaralabos Varelas
6. Fa-Xing Yu
7. Jixin Dong
8. Randy L. Johnson

In Molecular Biology

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2. Duojia Pan
3. Bin Zhao
4. G. Halder
5. Xaralabos Varelas
6. Jixin Dong
7. Q. Lei
8. Shian Wu

In Oncology

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2. Bin Zhao
3. Duojia Pan
4. Scott W. Lowe
5. Y. Xiong
6. G. Halder
7. J. Silke
8. Xaralabos Varelas

Citations in the corpus

• Force Triggers YAP Nuclear Entry by Regulating Transport across Nuclear Pores. (2017, positive): “Thus, the main effect of both substrate rigidity and mechanical stability was on import rates; and, consequently, import rates correlated well with the nuclear/cytosolic ratio of the EGFP-tagged constructs (Figure S6C).”
• Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach. (2006, background): “, 2001) and potentiates apoptosis in a manner that is suppressed by Akt (Basu et al., 2003).”
• FoxO transcription factors; Regulation by AKT and 14-3-3 proteins. (2011, background): “[65] S. Basu, N.F. Totty, M.S. Irwin, M. Sudol, J. Downward, Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis, Mol.”
• The Hippo Signaling Pathway in Development and Cancer (2010, background): “It is worth noting that besides its role as a potent oncogene, YAP has also been implicated as a potential tumor suppressor by potentiating p73-mediated apoptosis (Strano et al., 2001; Basu et al., 2003; Matallanas et al., 2007; Oka et al., 2008; Yuan et al., 2008).”
• The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation. (2010, background): “In fact, several transcription factors have been implicated as YAP targets, including the p53-related p73, RUNX2, the ErbB4 cytoplasmic domain, and TEAD (Yagi et al. 1999; Vassilev et al. 2001; Basu et al. 2003; Komuro et al. 2003).”
• The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control. (2008, background): “Phosphorylation of YAP at Ser127 has been implicated in mediating cytoplasmic sequestration (Basu et al., 2003).”
• The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease (2014, background): “14-3-3 binding fosters cytoplasmic sequestration (Basu et al., 2003; Kanai et al., 2000), and is one of the major mechanisms by which the Hippo pathway controls TAZ/YAP localization and activity.”
• Hippo signaling in organ size control. (2007, positive): “Huang et al. (2005) went on to show that YAP (yes-associated protein), the mammalian homolog of Yki, possesses similar activity to its Drosophila counterpart, suggesting that YAP likely functions as an oncogene instead of an apoptosis-promoting protein as previously reported (Basu et al. 2003).”
• The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP. (2005, background): “Along this line, it is worth noting that while F cthe reported ability of YAP to transactivate p73 in cultured mammalian cells is more suggestive of a tumor dsuppressor function for YAP (Basu et al., 2003), our tstudies clearly implicate Yki and YAP as potential oncop genes.”
• Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. (2007, background): “It has been previously reported that YAP2 S127 is phosphorylated by Akt/PKB (Basu et al. 2003).”
• The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass. (2009, background): “Phosphorylation of Yap-S112 by the protein kinase Lats promotes cytoplasmic localization of Yap through interaction with the cytoplasmic scaffold protein 14-3-3 (Basu et al., 2003; Dong et al., 2007; Zhao et al., 2007).”
• TAZ Promotes Cell Proliferation and Epithelial-Mesenchymal Transition and Is Inhibited by the Hippo Pathway (2008, background): “It has been reported that Akt/PKB was identified as a kinase that phosphorylated YAP at its 14-3-3 binding site and inhibited its transactivation function (1).”