Vitamin D2 is much less effective than vitamin D3 in humans.

By L. Armas, B. Hollis, R. Heaney. Journal of Clinical Endocrinology and Metabolism, 2004

1,190 citations recorded by the source corpus.

Subfields: Endocrinology, Diabetes and Metabolism, Nutrition and Dietetics, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/48c7e8ee0651781ca40c4ab14283850991ae5721

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrinology, Diabetes and Metabolism

In Nutrition and Dietetics

In Pathology and Forensic Medicine

Citations in the corpus

The vitamin D deficiency pandemic: Approaches for diagnosis, treatment and prevention (2017, background): “One study reported that vitamin D2 increased the destruction of vitamin D3 suggesting that ingestion of vitamin D2 increased risk for that patient becoming vitamin D deficient more quickly if vitamin D2 was used [51].”
Estimates of optimal vitamin D status (2005, background): “bConsistent with the recent observation that 1,000 IU of vitamin D3/d in orange juice maintained an average 25(OH)D level of 94±20 nmol/l [35]”
Position of the American Dietetic Association: vegetarian diets. (2009, background): “Although some research suggests that vitamin D-2 is less effective than vitamin D-3 in maintaining serum 25-hydroxyvitamin D levels (44) other studies find that vitamin D-2 and vitamin D-3 are equally effective (45).”
From vitamin D to hormone D: fundamentals of the vitamin D endocrine system essential for good health. (2008, background): “Given that vitamin D2 is significantly less biologically active in humans than is vitamin D3 (7), its biological use as a dietary supplement in the United States should be discontinued and its use in a high-dose form [eg, 500 000 IU/mL of ergocalciferol (vitamin D2)] in clinical studies (73, 74) and”
Vitamin D2 is as effective as vitamin D3 in maintaining circulating concentrations of 25-hydroxyvitamin D. (2008, background): “Recently, it was suggested that vitamin D2 was less effective than vitamin D3 in maintaining serum 25(OH)D levels when given either as 4000 IU/d for 2 wk (8) or as a single dose of 50,000 IU (9).”
Vitamin D deficiency in adults: when to test and how to treat. (2010, background): “A single dose of 50,000 IU of D 2 or D 3 produces a similar increase in the total 25(OH)D concentration, but the apparent longer half-life of D 3 suggests that less frequent dosing may be needed.(19) A daily dosing study of 1000 IU of D 2 vs D 3 showed no difference in any resulting vitamin D level ”
Nonclassic actions of vitamin D. (2009, background): “J Clin Endocrinol Metab, January 2009, 94(1):26–34 jcem.”
Vitamin D deficiency: a worldwide problem with health consequences. (2008, background): “There has been much discussion about vitamin D2 being only 30–50% as effective as vitamin D3 in maintaining serum concentrations of 25(OH)D (93, 94).”
Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials. (2005, background): “Previous studies, however, reported that the potency of ergocalciferol may be less than one third that of cholecalciferol in the same dose.(49,50)”