Elevations of Inflammatory and Procoagulant Biomarkers in Elderly Persons With Renal Insufficiency

By M. Shlipak, L. Fried, C. Crump, A. Bleyer, Teri Manolio, R. Tracy, C. Furberg, B. Psaty. Circulation, 2003

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Research Agenda for Frailty in Older Adults: Toward a Better Understanding of Physiology and Etiology: Summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older Adults (2006, background): “These included evidence for the activation of thrombotic pathways, either at baseline or in the physiologically stressful setting of infection or disease that triggers inflammatory mediators and their independent associations with frailty (as defined by some investigators) and of other poor health o”
Increased prevalence of oxidant stress and inflammation in patients with moderate to severe chronic kidney disease. (2004, background): “In baseline data from the Cardiovascular Health Study, levels of CRP and IL-6 were found to be significantly higher in patients with renal insufficiency compared to patients with normal kidney function [35].”
Factors influencing serum cystatin C levels other than renal function and the impact on renal function measurement. (2004, background): “These associations are thus not due to the fact that factors as obesity [17–20], smoking [21, 22] and CRP [23, 24] are related to renal function.”