Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia.

By T. Somervaille, M. Cleary. Cancer Cell, 2006

604 citations recorded by the source corpus.

Subfields: Hematology, Immunology

View Paper: https://www.semanticscholar.org/paper/485b7fcf389161da0e53bda999a7e1d7b40f6ba5

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Hematology

1. G. Lindeman
2. Andrei Krivtsov
3. Scott A. Armstrong
4. M. Clarke
5. Jane E. Visvader
6. S. Morrison
7. Charlotte Kuperwasser
8. Christine M. Fillmore

In Immunology

1. M. Clarke
2. Jane E. Visvader
3. G. Lindeman
4. S. Morrison
5. Charlotte Kuperwasser
6. Christine M. Fillmore

Citations in the corpus

• Cancer stem cells: current status and evolving complexities. (2012, background): “Indeed, there is substantial evidence that restricted progenitors can generate LSCs by the reactivation of distinct self-renewal programs (Krivtsov et al., Cell Stem Cell 10, June 14, 2012 ª2012 Elsevier Inc. 721 2006; Somervaille and Cleary, 2006; Somervaille et al., 2009).”
• Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypically diverse progeny and survive chemotherapy (2008, positive): “Because serial colony-forming unit (CFU) assays have been used to assay stem cell self-renewal in other systems [26], we examined whether sorted CD44+/CD24-/ ESA+ cells contain more serial CFUs than other subpopulations.”
• MLL translocations, histone modifications and leukaemia stem-cell development (2007, background): “Expression of MLL–AF9 in GMPs leads to leukaemogenic transformation of GMPs to LSC”
• The biology of cancer stem cells. (2007, background): “…it is easier to transform them into LSCs. Nonetheless, not all the leukemia cells in the leukemias arising from these progenitor cells were capable of giving rise to new tumors, suggesting that the LSCs gave rise to both self-renewing and nonself-renewing leukemia cells (Somervaille & Cleary 2006).”
• Cancer stem cells: impact, heterogeneity, and uncertainty. (2012, background): “Mouse AMLs induced by MLL-AF9 expression appear to have much higher frequencies of leukemogenic cells than observed after Pten deletion (Krivtsov et al., 2006; Somervaille and Cleary, 2006; Somervaille et al., 2009).”