Can yeast glycolysis be understood in terms of in vitro kinetics of the constituent enzymes? Testing biochemistry.

By Bas Teusink, J. Passarge, C. A. Reijenga, E. Esgalhado, C. C. V. D. Weijden, M. Schepper, M. Walsh, Barbara M. Bakker, K. Dam, Hans V. Westerhoff and 1 more. European Journal of Biochemistry, 2000

761 citations recorded by the source corpus.

Subfields: Food Science, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/4816c1279ebc007ed34ee34995b455e3be678460

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Citations in the corpus

Flux balance analysis in the era of metabolomics (2006, background): “A variety of techniques for metabolic network analysis have been developed, including kinetic modelling, which considers concentrations of compounds [17]; metabolic control analysis (MCA), which evaluates the effects of small variations of enzyme or metabolite concentrations [13]; and most recently,”
Cancer: a Systems Biology disease. (2006, background): “Several detailed kinetic models ('computer replica') of metabolic systems , such as glycolysis (Schuster and Holzhütter, 1995; Teusink et al., 2000), provide rather accurate descriptions of their in vivo counterparts.”
Universally Sloppy Parameter Sensitivities in Systems Biology Models (2007, methodology): “[10] Teusink B, Passarge J, Reijenga CA, Esgalhado E, van der Weijden CC, et al.”
Network dynamics and cell physiology (2001, background): “Other examples • Metabolic regulation: Fell(80), Schilling & Palsson(81), Teusink et al.(82) • Cyclic AMP signalling: Martiel & Goldbeter(83), Tyson & Murray(19) • Calcium oscillations: Dupont & Goldbeter(20), De Young & Keizer(84) • Bacterial physiology: Mahaffy & Zyskind(85), Bray et al.”
Plant metabolomics: large-scale phytochemistry in the functional genomics era. (2003, methodology): “A recent example is the model of yeast glycolysis by Teusink and coworkers (Teusink et al., 2000) and its improvement by Pritchard and Kell (2002).”
Introduction to systems biology. (2007, background): “[80, 81] constructed a kinetic model of yeast glycolysis that was quite helpful in solving the puzzle of an unexpected phenotype of a particular mutant strain and at the same time lead to a surprising new insight about glycolysis.”
The effects of temperature on aerobic metabolism: towards a mechanistic understanding of the responses of ectotherms to a changing environment (2015, background): “It also points out a more general caveat associated with measurements of TPCs on isolated enzymes, because activities measured in vitro often do not match those measured in vivo (Wright et al., 1992; Teusink et al., 2000).”