Flux balance analysis in the era of metabolomics

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Applications of genome-scale metabolic reconstructions (2009, background): “Many of the constraint-based analyses possible on metabolic GENREs rely on the theory that evolution selects for fitness-optimizing organisms, a concept crystallized with the development of flux balance analysis (FBA) (Maynard Smith, 1978; Lee et al, 2006).”
Flux balance analysis of biological systems: applications and challenges (2009, background): “Furthermore, FBA can also cope with the uncertainty and incompleteness in metabolomic data, since it allows for the incorporation of partial metabolic information [62].”
OptForce: An Optimization Procedure for Identifying All Genetic Manipulations Leading to Targeted Overproductions (2010, background): “Flux balance analysis (FBA) has emerged as an important framework [16–19] to assess the metabolic potential of a microbial production system.”
Environments that Induce Synthetic Microbial Ecosystems (2010, result): “Similar to the cycles of refinement for individual genome scale stoichiometric models [49–51], we expect that the results from biological experimentation can feed back into refinement of models and algorithms for predicting interactions.”