HuR and mRNA stability

By C. Brennan, J. Steitz. Cellular and Molecular Life Sciences (CMLS), 2001

1,137 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/47c3cc455a6fcd2f84b6b2c2db42ba47e51bb1a7

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Citations in the corpus

Transcriptome-wide analysis of regulatory interactions of the RNA-binding protein HuR. (2011, background): “In the cytoplasm, Hu proteins can stabilize mRNAs by binding to AU-rich elements (AREs) within 3'UTRs (Brennan & Steitz, 2001), consistent with in vitro studies of HuR (Hinman & Lou, 2008, and references within).”
MyD88-mediated stabilization of interferon-γ-induced cytokine and chemokine mRNA (2006, neutral): “, increase mRNA stability by interacting with adenine-uridine–rich binding protein”
Mechanisms of miRNA-Mediated Gene Regulation from Common Downregulation to mRNA-Specific Upregulation (2014, background): “HuR shuffles between nucleus and cytoplasm and was found to play a vital role in different posttranscriptional pathways not only in stress responses, but also in cell proliferation, differentiation, tumorigenesis, and immune responses [148, 149].”
N6-methyl-adenosine (m6A) in RNA: An Old Modification with A Novel Epigenetic Function (2012, background): “As an example, ELAV1/HuR, a potential m(6)A-binding protein, was able to bind to the ARE region and stabilize corresponding transcripts [92].”
Vascular endothelial growth factor in eye disease. (2008, background): “…of VEGF mRNA increases by two to three-fold (Levy et al., 1996) due to a stabilizing effect of HuR, a 36 kDa RNA-binding protein, which binds with high affinity to AREs in the 3′-UTR of VEGF mRNA, protecting it from degradation by endonucleases (Brennan and Steitz, 2001; Robinow et al., 1988).”
Integrative regulatory mapping indicates that the RNA-binding protein HuR (ELAVL1) couples pre-mRNA processing and mRNA stability (2011, background): “Since early studies found roles in nuclear export and mRNA stability (Brennan and Steitz, 2001), the role of HuR in nuclear pre-mRNA events has by and large not been investigated.”
Diverse molecular functions of Hu proteins (2008, neutral): “Although numerous Hu mRNA stabilization targets have been identified (reviewed in [17,19,45,69]), the mechanisms by which Hu proteins stabilize mRNAs are only partially characterized, with the most known about the ubiquitously expressed family member, HuR.”
N6-methyladenosine Modulates Messenger RNA Translation Efficiency (2015, neutral): “HuR stabilizes ARE mRNA, and such stabilization is more significant during nutrition shortage (Brennan and Steitz, 2001; Yaman et al., 2002).”