The role of dopamine in the pathophysiology of depression.

By B. Dunlop, C. Nemeroff. Archives of General Psychiatry, 2007

1,247 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/478b8c8b058e4456417dee568e767aa43f0efcad

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In Cellular and Molecular Neuroscience

In Psychiatry and Mental health

Diego A. Pizzagalli

Citations in the corpus

Understanding resilience (2013, background): “Some studies have found decreased levels of circulating dopamine in depression and elevated urinary and plasma dopamine concentrations in PTSD (Charney, 2004; Dunlop and Nemeroff, 2007).”
Depression, Stress, and Anhedonia: Toward a Synthesis and Integrated Model (2014, background): “Owing to these findings, interest in the role of DA in the pathophysiology of depression has resurfaced (e.g., Dunlop & Nemeroff 2007).”
Worth the ‘EEfRT’? The Effort Expenditure for Rewards Task as an Objective Measure of Motivation and Anhedonia (2009, background): “Not surprisingly, several theorists have proposed that the symptoms of anhedonia in humans, specifically symptoms of reduced motivation or wanting, are related to a deficiency of DA signaling in the ventral striatum [33,34].”
Effects of Early Life Stress on Cognitive and Affective Function: An Integrated Review of Human Literature (2010, background): “Blunted mesolimbic DA transmission has been postulated in depression, particularly in the presence of anhedonia, low energy, loss of libido, and apathy (Dunlop and Nemeroff 2007; Hasler et al. 2008; Pizzagalli et al. 2009a, b).”
Reconsidering Anhedonia in Depression: Lessons from Translational Neuroscience (2010, background): “…described below), subsequent research using neuroimaging, pharmacological and genetic methods in both humans and animals has provided some support for the claim that DA function is impaired in at least a sub-population of individuals with MDD (Dunlop and Nemeroff, 2007; Yadid and Friedman, 2008).”
Cognitive bias as an indicator of animal emotion and welfare: Emerging evidence and underlying mechanisms (2009, background): “How might these reward-evaluation systems be influenced by affective state and hence alter the relative valuation of positive or negative outcomes in a judgement bias task? Activity of the DA system appears to be sensitive to environmental stressors and to be associatedwithmood disorders such as dep”
Inflammatory Cytokines in Depression: Neurobiological Mechanisms and Therapeutic Implications (2013, background): “…2007, Furman et al., 2011, Capuron et al., 2012), and changes in DA synthesis, release and/or receptor signaling have been proposed as potential mechanisms that may contribute to anhedonic and psychomotor symptoms (Willner, 1983, Dunlop and Nemeroff, 2007, Stein, 2008, Felger and Miller, 2012).”
The Link between Depression and Chronic Pain: Neural Mechanisms in the Brain (2017, background): “The fact that dopaminergic drugs, such as pramipexole, are effective drugs for depression inhibition suggests that enhancing DA function may form at least a partial basis for treatment response of MDD [111].”