Multiple pathways control protein kinase C phosphorylation

By D. Parekh, W. Ziegler, P. Parker. EMBO Journal, 2000

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How researchers see this paper

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Protein kinase C and other diacylglycerol effectors in cancer (2007, background): “The mechanisms involved in PKC activation have been extensively studie”
Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling (2008, background): “In contrast, phosphorylations of all three sites in PKC are constitutive, whereas binding of second messengers, such as DAG and calcium, to regulatory domain provides the major signal input for PKC activation (Parekh et al, 2000; Newton, 2003).”
Reactive Oxygen Species in Inflammation and Tissue Injury (2014, positive): “The atypical PKCs (f, k) are regulated by PS and are independent of DAG and Ca(2) + (250, 334).”
Structural Basis of Protein Kinase C Isoform Function (2008, background): “The “priming” Ser/Thr phosphorylations that lock the enzyme in a closed, stabilized, catalytically-competent, phosphatase/ protease-resistant conformation have only recently become the focus of research interest (141, 153).”