Pillars Article: Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions

By N. Hozumi, S. Tonegawa. 2004

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Unraveling V(D)J Recombination: Insights into Gene Regulation (2004, unknown): “While the RNA hybridized to two specific fragments from embryo DNA,in early embryonic development a genetic process for which there is no available precedent (Burnet 1957).” it hybridized to a novel fragment from the plasmacytoma DNA (Hozumi and Tonegawa, 1976).”
Assessment of the Evolution of Cancer Treatment Therapies (2011, background): “In 1976, genetic studies by Susumu Tonegawa revealed the basis for the vast diversity of antibodies, identifying the process of somatic recombination in immunoglobulin genes [35].”
Maximum entropy models for antibody diversity (2009, background): “Classical work has emphasized the combinatorial diversity generated by piecing together different segments of the antibody molecule, each of which is encoded in the genome (17).”
Quantifying lymphocyte receptor diversity (2016, unknown): “These segments are combinatorically picked out of several genomic templates for each type, in a process called V(D)J recombination [4], as schematized in Fig.”
Interchromosomal interactions and olfactory receptor choice. (2006, background): “…site, as observed for trypanosome surface antigens and B and T cell antigen receptors, provides a mechanism to stochastically express one member of a set of genes that mediate cellular interactions with the environment (Van der Ploeg, 1991; Navarro and Gull, 2001; Hozumi and Tonegawa, 1976).”