Nuclear factor-?B1: Regulation and function

By S. G. Pereira, F. Oakley. 2008

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Induction and regulatory function of miR-9 in human monocytes and neutrophils exposed to proinflammatory signals (2009, background): “Interestingly, the nfkb1 gene encodes 2 functional proteins (p50 and its precursor p105) with distinct biological activities during LPS responses (33).”
Transcriptomic responses to heat stress and bleaching in the elkhorn coral Acropora palmata (2010, background): “The p105 precursor is posttranslationally modified to generate the p50 subunit (RHD-containing transcription factor) and I-κB (an inhibitor of the p50 subunit containing the ARD and DD) (Pereira & Oakley 2008).”
Flavonoids as anti-inflammatory agents: implications in cancer and cardiovascular disease (2009, background): “Another control point of gene expression is the NF-jB transcriptional system, which is a major effector pathway involved in inflammation and innate immune responses [115].”
Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-kappaB-Dependent Manner. (2010, background): “When active, the NF-kB heterodimer (RelA-p50) translocates to the nucleus, where it activates the transcription of its target genes (Karin and Ben-Neriah, 2000; Pereira and Oakley, 2008).”