LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex

By S. Mi, X. Lee, Z. Shao, G. Thill, B. Ji, J. Relton, M. Lévesque, N. Allaire, S. Perrin, Bryan Sands and 4 more. Nature Neuroscience, 2004

862 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience

View Paper: https://www.semanticscholar.org/paper/471b0f9762bd0effda6eb44d037e96f125325fa8

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. G. Ferraro
2. L. Mckerracher
3. Robin J. M. Franklin
4. A. Fournier
5. Zhigang He
6. S. Y. Ng
7. A. Lee
8. B. Trapp

In Developmental Neuroscience

1. Robin J. M. Franklin
2. Mark Kotter
3. Chao Zhao
4. Wen-Wu Li
5. G. Ferraro
6. L. Mckerracher
7. A. Fournier
8. Zhigang He

Citations in the corpus

• Proinflammatory cytokine synthesis in the injured mouse spinal cord: Multiphasic expression pattern and identification of the cell types involved (2007, background): “Interleukin-1 (IL-1 ) also appears to be a key regulator of WD in the injured peripheral and central nervous system (Shamash et al., 2002; Mi et al., 2004).”
• Traumatic Brain Injuries: Pathophysiology and Potential Therapeutic Targets (2019, background): “Intriguingly, these myelin-associated inhibitors bind specifically to Nogo receptor (NgR) complex on neuronal membrane, which consists of the co-receptors p75NTR, Troy and LINGO-1 (Wang et al., 2002; Mi et al., 2004; Park et al., 2005).”
• Rho signaling and axon regeneration. (2012, background): “In many neurons, TROY substitutes for p75NTR, and other proteins such as Lingo-1 participate as components of the NgR1 complex (Mi et al., 2004; Park et al., 2005; Shao et al., 2005).”
• Myelin Impairs CNS Remyelination by Inhibiting Oligodendrocyte Precursor Cell Differentiation (2006, background): “However, especially relevant in this regard is the recent report that activation of LINGO inhibits O4ϩ immature oligodendrocytes from maturing into differentiated oligodendrocytes, by promoting the activity of RhoA GTPase while suppressing that of Fyn tyrosine kinase (Mi et al., 2005).”
• LINGO-1 negatively regulates myelination by oligodendrocytes (2005, background): “It is selectively expressed in brain and spinal cord and functions as a component of the NgR1/p75 and NgR1/Taj(Troy) signaling complexes that regulate CNS axon growt”
• From basics to clinical: a comprehensive review on spinal cord injury. (2014, background): “, 2005) and LINGO-1 (Mi et al., 2004), and only working together they can transmit inhibitory signals to the axon,”