TNF-α Is a Predictor of Insulin Resistance in Human Pregnancy

By J. Kirwan, S. H. Mouzon, J. Lepercq, J. Challier, L. Huston-Presley, J. Friedman, S. Kalhan, P. Catalano. 2002

655 citations recorded by the source corpus.

Subfields: Obstetrics and Gynecology, Pediatrics, Perinatology and Child Health

View Paper: https://www.semanticscholar.org/paper/4704ad109511144995fbb744d767a6378016dde5

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In Pediatrics, Perinatology and Child Health

1. A. Sinclair

Citations in the corpus

• Host remodeling of the gut microbiome and metabolic changes during pregnancy. (2012, background): “Reduced insulin sensitivity has been correlated with changes in immune status in pregnancy, including elevated levels of circulating cytokines (e.g., TNF-a and IL-6; Kirwan et al., 2002) that are thought to drive obesity-associated metabolic inflammation (Gregor and Hotamisligil, 2011).”
• Dietary intakes and food sources of omega-6 and omega-3 polyunsaturated fatty acids (2003, background): “With progression of pregnancy, insulin sensitivity decreases between 50 and 70% (Butte, 2000), which in turn causes increased circulation of metabolic fuels, such amino acids, glucose and fatty acids (Kirwan et al., 2002; Nelson et al., 2010; Wada et al., 2010).”