Superoxide activates mitochondrial uncoupling proteins
By K. Echtay, D. Roussel, J. St-Pierre, M. Jekabsons, S. Cadenas, J. Stuart, James A. Harper, Stephen J Roebuck, Alastair D. Morrison, S. Pickering and 2 more. Nature, 2002
1,398 citations recorded by the source corpus.
Subfields: Cell Biology, Molecular Biology, Physiology
View Paper: https://www.semanticscholar.org/paper/46efcaf382ab9273f6d179203f17be978e0fc591
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In Cell Biology
- B. Spiegelman
- Christoph Handschin
- Jiandie D. Lin
- E. Dale Abel
- Reem M. Sallam
- M. Liesa
- A. Alfadda
- D. Hardie
In Molecular Biology
- Christoph Handschin
- B. Spiegelman
- M. Juhaszova
- Jiandie D. Lin
- Wenli Yang
- D. Zorov
- Steven J. Sollott
- Marc Uldry
In Physiology
- B. Spiegelman
- Christoph Handschin
- E. Weitzberg
- Jiandie D. Lin
- Wenli Yang
- Marc Uldry
- J. Lundberg
- J. St-Pierre
Citations in the corpus
- Dietary inorganic nitrate improves mitochondrial efficiency in humans. (2011, background): “…(Rolfe et al., 1994), proton slip (Groen et al., 1990), energetic cost of metabolite transport (Klingenberg, 1970), or physiological uncoupling (Echtay et al., 2002). etabolism 13, 149–159, February 2, 2011 ª2011 Elsevier Inc. 149 (A and B) (A) Plasma levels of nitrate and (B) nitrite…”
- Mitochondrial Energetics in the Heart in Obesity-Related Diabetes (2007, background): “UCP proteins can be allosterically activated by superoxides (reactive oxygen species [ROS]) (18,19) and ROS by-products such as carboncentered radicals (20), hydroperoxy fatty acids (21,22), and lipid peroxidation products, e.”
- Mechanisms of sepsis-induced cardiac dysfunction (2007, background): “By inhibiting the electron transport chain, NO and ONOO could decrease superoxide production (89).”
- Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release. (2014, background): “Later, it was demonstrated that superoxide directly activates UCPs resulting in a negative feedback controlling both ROS production and their levels (120).”
- Essential fatty acids: biochemistry, physiology and pathology (2006, background): “Superoxide anion activates UCPs [148], which limits further superoxide anion generation by dissipating the protonmotive force.”