Arabidopsis NAC1 transduces auxin signal downstream of TIR1 to promote lateral root development.

By Qipeng Xie, G. Frugis, D. Colgan, Nam-Hai Chua. Genes & Development, 2000

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Auxin plays a key role in lateral root formation, but the signaling pathway for this process is poorly understood. We show here that NAC1, a new member of the NAC family, is induced by auxin and mediates auxin signaling to promote lateral root development. NAC1 is a transcription activator consisting of an N-terminal conserved NAC-domain that binds to DNA and a C-terminal activation domain. This factor activates the expression of two downstream auxin-responsive genes, DBP and AIR3. Transgenic plants expressing sense or antisense NAC1 cDNA show an increase or reduction of lateral roots, respectively. Finally, TIR1-induced lateral root development is blocked by expression of antisense NAC1 cDNA, and NAC1 overexpression can restore lateral root formation in the auxin-response mutant tir1, indicating that NAC1 acts downstream of TIR1.

Subfields: Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/46b445f969930b50cbdff27ea67d572aa2872b2f

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Citations in the corpus

Characterization of transcription factor gene SNAC2 conferring cold and salt tolerance in rice (2008, background): “mediates auxin signaling to promote lateral root development (Xie et al. 2000).”
Auxin: the looping star in plant development. (2008, background): “In the process of lateral root initiation this signaling is likely to be fine tuned by NAC1, a transcriptional activator of the NAM, ATAF, CUC family, which is targeted to the proteasome by the RING-finger protein SINA of Arabidopsis thaliana 5 (SINAT5)-dependent ubiquitination, thereby regulating a”
Auxin: regulation, action, and interaction. (2005, background): “For example, lateral root proliferation in response to auxin is mediated by the transcription factor encoded by the auxin-induced NAC1 gene, which acts downstream of TIR1 (Xie et al., 2000).”
The Arabidopsis Cold-Responsive Transcriptome and Its Regulation by ICE1w⃞ (2005, background): “…NAC family transcription factors have a conserved NAC domain at the N termini of the proteins (Olsen et al., 2005) and have been implicated in plant development (Souer et al., 1996; Aida et al., 1997; Sablowski and Meyerowitz, 1998; Xie et al., 2000; Takada et al., 2001; Vroemen et al., 2003).”
AtNAC2, a transcription factor downstream of ethylene and auxin signaling pathways, is involved in salt stress response and lateral root development. (2005, background): “8%) and NAC1 (34.4%; Xie et al., 2000).”
ARF7 and ARF19 Regulate Lateral Root Formation via Direct Activation of LBD/ASL Genes in Arabidopsis[W] (2007, background): “Although not identified as a candidate target of ARF7 and ARF19 (Okushima et al., 2005), expression of NAC1, a positive regulator of lateral root formation downstream of auxin signaling (Xie et al., 2000, 2002; Guo et al., 2005), was examined.”
Auxin-responsive gene expression: genes, promoters and regulatory factors (2002, background): “, 1999), the recently described auxininducible NAC1 gene from Arabidopsis (Xie et al., 2000) and, perhaps, a mitogen-activated protein kinase (MAPK) gene (Mockaitis and Howell, 2000).”
The NAC Transcription Factors NST1 and NST2 of Arabidopsis Regulate Secondary Wall Thickenings and Are Required for Anther Dehiscencew⃞ (2005, background): “CUP-SHAPED COTYLEDON1 (CUC1), CUC2, and CUC3, which regulate organ separation and meristem formation (Aida et al., 1997; Takada et al., 2001; Vroemen et al., 2003), and NAC1, which regulates lateral root development (Xie et al., 2000), are classified into subgroup IIa.”
Specific effects of microRNAs on the plant transcriptome. (2005, background): “Another predicted target, NAC1 (Rhoades et al., 2002), mediates auxin signals during lateral root development ( Xie et al., 2000 ).”
Monitoring Expression Profiles of Rice Genes under Cold, Drought, and High-Salinity Stresses and Abscisic Acid Application Using cDNA Microarray and RNA Gel-Blot Analyses1[w] (2003, background): “NACs are a family of genes specific to plants and are found to play a role in a diverse set of developmental processes including formation and maintenance of shoot apical meristem and floral morphogenesis (Kikuchi et al., 2000; Xie et al., 2000).”
A Bioinformatic Analysis of NAC Genes for Plant Cell Wall Development in Relation to Lignocellulosic Bioenergy Production (2009, background): “The AtNST and AtVND proteins associated with secondary wall formation during fiber development and xylem differentiation, all grouped into the NAC-c subfamily, while the NAC genes that function in organ initiation and differentiation seem to be grouped into the NAC-d subfamily [36] (Table S3).”
Transcription switches for protoxylem and metaxylem vessel formation. (2005, background): “Several reports also indicated that NAC-domain proteins play pivotal roles, such as during morphogenesis and in hormone signaling in plants (Aida et al. 1997; Sablowski and Meyerowitz 1998; Xie et al. 2000; Duval et al. 2002; Tran et al. 2004).”