Forkhead Transcription Factor FKHR-L1 Modulates Cytokine-Dependent Transcriptional Regulation of p27KIP1

By P. Dijkers, René H Medema, Cornelieke Pals, L. Banerji, N. Thomas, Eric W.-F. Lam, B. Burgering, J. Raaijmakers, Jan-Willem J. Lammers, L. Koenderman and 1 more. Molecular and Cellular Biology, 2000

620 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/46773a225b25d2da91ace50c16252a83d146936e

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Citations in the corpus

• FoxO transcription factors in the maintenance of cellular homeostasis during aging. (2008, background): “FoxO-dependent transcription plays an important role in a wide variety of cellular outputs, including glucose metabolism, cell cycle arrest, differentiation, detoxification of reactive oxygen species (ROS), repair of damaged DNA, and apoptosis [17–26].”
• The phosphatidylinositol 3-Kinase–AKT pathway in human cancer (2002, background): “The effects on KIP1 seem to be transcriptional and mediated by FKHR, which represses CDKN1B (the gene that encodes KIP1) expressio”
• The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy (2008, background): “Forkhead box class O family (FoxO) proteins activate CDKN1B transcription, in response to cytokines or promyelocytic leukaemia protein ( PML ) and nuclear Akt signallin”
• FOXO transcription factors at the interface between longevity and tumor suppression (2005, background): “…growth factor I (IGF-I) (Brunet et al., 1999; Rena et al., 1999), insulin (Kops and Burgering, 1999; Nakae et al., 1999), interleukin 3 (Dijkers et al., 2000a), erythropoietin (Kashii et al., 2000), epidermal growth factor (Jackson et al., 2000), and nerve growth factor (Zheng et al.,…”
• FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. (2007, neutral): “PTEN’s diverse tumor suppressor role in different cell lineages is further evidenced by the cancer-prone condition in germline and conditional Pten mutant mice, which develop carcinomas of the skin, prostate, colon, breast, and endometrium, as well as thymic lymphomas, among other cancers ( Di Crist”
• Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways (2017, background): “AKT also inhibits FOXO1, which normally induces the transcription of p27KIP1 and p21WAF1 [480,481].”