Cortactin promotes and stabilizes Arp2/3-induced actin filament network formation.

By Alissa M. Weaver, A. Karginov, Andrew W. Kinley, Scott A. Weed, Yan Li, J. Parsons, J. Cooper. Current Biology, 2001

624 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Biophysics, Cell Biology

View Paper: https://www.semanticscholar.org/paper/466f95418130aac1da4519352f335b2e865e5f00

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In Biomedical Engineering

1. Thomas D. Pollard
2. J. Condeelis
3. John M. Koomen
4. T. Svitkina
5. Pengfei Lu

In Biophysics

1. Thomas D. Pollard
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1. T. Svitkina
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Citations in the corpus

• Actin and Actin-Binding Proteins. (2016, background): “The protein cortactin stabilizes branches (Weaver et al. 2001), but both cofilin (Chan et al.”
• Actin assembly and endocytosis: from yeast to mammals. (2003, background): “Syndapin and intersectin-l bind to N-WASP (Hussain et al. 2001, Qualmann et al. 1999), a potent activator of the Arp2/3 complex, whereas cortactin and yeast Abp1 can directly activate the Arp2/3 complex (Goode et al. 2001, Uruno et al. 2001, Weaver et al. 2001).”
• Regulation of actin assembly associated with protrusion and adhesion in cell migration. (2008, background): “The acidic domain and the tandem repeats are sufficient to stimulate the Arp2/3 complex (230, 243).”
• Mechanism of filopodia initiation by reorganization of a dendritic network (2003, background): “, 2002), cortactin stabilizes branches (Weaver et al., 2001), and filamin A (Flanagan et al.”
• HDAC6 modulates cell motility by altering the acetylation level of cortactin. (2007, background): “[PubMed: 9683637] Weed SA, Karginov AV, Schafer DA, Weaver AM, Kinley AW, Cooper JA, Parsons JT. Cortactin localization to sites of actin assembly in lamellipodia requires interactions with F-actin and the Arp2/3 complex.”
• Cellular motility driven by assembly and disassembly of actin filaments. (2003, positive): “WASp and N-WASP are activates (Uruno et al., 2001; Weaver et al., 2001) Arp2/3 intrinsically autoinhibited by the interaction of the GTPase binding complex, as well as stabilizing branches.”
• Foot and mouth: podosomes, invadopodia and circular dorsal ruffles (2004, neutral): “Cortactin contains an amino-terminal Arp2/3 binding sit”
• Chemotaxis in cancer (2011, background): “Cortactin (CTTN) regulation of cofilin and NWASP is important in the control of the stages of invadopodium assembly and maturatio”