Inhibition of quorum sensing in Pseudomonas aeruginosa biofilm bacteria by a halogenated furanone compound.

By M. Hentzer, K. Riedel, T. B. Rasmussen, A. Heydorn, J. B. Andersen, M. Parsek, S. Rice, L. Eberl, Søren Molin, Niels Høiby and 2 more. Microbiology, 2002

1,022 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/46382f2bb0990f92e9c044b8e963915ecab53db9

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biomedical Engineering

1. M. Givskov
2. Anton Hartmann
3. B. Bassler

In Molecular Biology

1. T. Bjarnsholt
2. M. Givskov
3. J. Kaplan
4. P. Nannipieri
5. Søren Molin
6. P. Watnick
7. E. Karatan
8. T. Defoirdt

Citations in the corpus

• Disruption of bacterial quorum sensing: an unexplored strategy to fight infections in aquaculture (2004, background): “Synthetic AHL-mediated quorum sensing antagonists Based on the findings mentioned above, several research groups started to investigate the activities of different synthetic AHL and furanone analogues with respect to quorum sensing (Reverchon et al., 2002; Smith et al., 2003a; Hentzer et al., 2002).”
• The effects of antibiotics on the microbiome throughout development and alternative approaches for therapeutic modulation (2016, background): “be pharmacologically inhibited in a variety of ways, including destruction of the QS signal [99], acceleration of turnover of key QS proteins [100–102], and competition with the QS signal for binding to key regulatory proteins [103–105].”
• Signalling: Listening in on bacteria: acyl-homoserine lactone signalling (2002, neutral): “The eukaryotic red alga Delisea pulchra releases halogenated furanones that can inhibit acyl-HSL-based signalling pathway”
• CHEMICAL DEFENSE IN A MARINE ALGA: HERITABILITY AND THE POTENTIAL FOR SELECTION BY HERBIVORES (2004, background): “Furanones further affect a range of bacterial phenotypes via interference with specific signalbased bacterial regulatory systems (Manefield et al. 1999, Hentzer et al. 2002).”
• The role of root exudates in rhizosphere interactions with plants and other organisms. (2006, background): “These compounds are structurally similar to bacterial AHLs and are capable of interfering with QS-controlled processes such as swarming and bioluminescence (59), as well as production of virulence factors and biofilm formation in Pseudomonas aeruginosa (76).”
• Screening for Quorum-Sensing Inhibitors (QSI) by Use of a Novel Genetic System, the QSI Selector (2005, methodology): “The QS monitor PAO1 (lasB-gfp) (23) was incubated with 2% (solid squares), 1% (solid triangles), 0.”
• Are root exudates more important than other sources of rhizodeposits in structuring rhizosphere bacterial communities? (2010, background): “…(unidentified) that interfere with bacterial quorum sensing: this is a prerequisite for the expression of many bacterial genes involved in both pathogenic and beneficial plant–microorganism interactions (Hentzer et al., 2002; Bauer & Mathesius, 2004; Bais et al., 2006; Degrassi et al., 2007).”
• Indole as an intercellular signal in microbial communities. (2010, background): “Antivirulence compounds are an important tool for fighting infectious diseases because, unlike antimicrobials, antivirulence compounds such as 7-hydroxyindole do not affect cell growth (Lee et al., 2009a), so there is less chance of developing resistance (Hentzer et al., 2002; Lesic et al., 2007).”
• Application of Quorum Quenching to Inhibit Biofilm Formation (2009, neutral): “Also, Hentzer et al .”
• Biofilm Dispersal: Mechanisms, Clinical Implications, and Potential Therapeutic Uses (2010, background): “4E), a synthetic inhibitor of AHL signaling, induces biofilm dispersal (Hentzer et al., 2002).”
• Biofilm-Related Infections: Bridging the Gap between Clinical Management and Fundamental Aspects of Recalcitrance toward Antibiotics (2014, background): “Along with AHLs, synthetic furanones derived from an algal metabolite now constitute potential prevention candidates, as they inhibit Gram-negative bacterial QS through their fixation to LasR and inhibition of the action of AHLs (288, 307).”
• Biofilms as Promoters of Bacterial Antibiotic Resistance and Tolerance (2020, background): “Thus, they function as antagonist of LuxR and repress expression of QS-induced genes [211,212].”