Caspase-1 induced pyroptotic cell death
By Edward A. Miao, Jayant V. Rajan, Alan Aderem. Immunological Reviews, 2011
1,085 citations recorded by the source corpus.
Summary: Programmed cell death is a necessary part of development and tissue homeostasis enabling the removal of unwanted cells. In the setting of infectious disease, cells that have been commandeered by microbial pathogens become detrimental to the host. When macrophages and dendritic cells are compromised in this way, they can be lysed by pyroptosis, a cell death mechanism that is distinct from apoptosis and oncosis/necrosis. Pyroptosis is triggered by Caspase‐1 after its activation by various inflammasomes and results in lysis of the affected cell. Both pyroptosis and apoptosis are programmed cell death mechanisms but are dependent on different caspases, unlike oncosis. Similar to oncosis and unlike apoptosis, pyroptosis results in cellular lysis and release of the cytosolic contents to the extracellular space. This event is predicted to be inherently inflammatory and coincides with interleukin‐1β (IL‐1β) and IL‐18 secretion. We discuss the role of distinct inflammasomes, including NLRC4, NLRP3, and AIM2, as well as the role of the ASC focus in Caspase‐1 signaling. We further review the importance of pyroptosis in vivo as a potent mechanism to clear intracellular pathogens.
Subfields: Immunology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/46118911e8ab7a596120dbe15f8ffa04e43650de
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In Immunology
In Molecular Biology
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- P. Lei
- Eric I. Elliott
- Shu-ting Zhang
- G. Cingolani
- F. Sutterwala
- E. Alnemri
- Qing-zhang Tuo
Citations in the corpus
- Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death (2017, positive): “Pyroptosis is triggered primarily by activation of the inflammatory caspases, which include caspase-1 and caspase-11 (caspase-4/-5 in humans) 3,4 .”
- Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications (2021, background): “Activated caspase‐1 in inflammasomes can trigger pyroptosis during cerebral ischemia.(330,433,434) VX‐765, a caspase‐1 inhibitor, can ameliorate infarct volumes, neurological deficits, and neuronal injury after MCAO.”
- Initiation and perpetuation of NLRP3 inflammasome activation and assembly (2015, background): “Caspase-1 activation leads to cytokine processing and secretion and in some circumstances results in pyroptotic cell death, which remains poorly understood (180, 181).”
- NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation and fibrosis (2014, background): “It has been suggested that pyroptosis may occur in cells (such as hepatocytes) that are not well equipped for secretion of cytokines following inflammasome mediated Casp1 activation.(25)”