To differentiate or not — routes towards metastasis

By Thomas Brabletz. Nature Reviews. Cancer, 2012

617 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/45d96fdc5ce494a8104d0dce5dcb8e0b37ac5069

How researchers see this paper

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In Molecular Biology

1. Herbert Levine
2. José N. Onuchic
3. Martin Weigt

In Oncology

1. D. Bar-Sagi

Citations in the corpus

• EMT subtype influences epithelial plasticity and mode of cell migration (2018, background): “This process is often conceptualized as the end result of EMT leading to the dissemination of single tumor cells (Brabletz, 2012; Lamouille et al., 2014; Nieto et al., 2016; Savagner, 2015).”
• EMERGING BIOLOGICAL PRINCIPLES OF METASTASIS (2017, neutral): “This reversion to an epithelial state should restore many of the cellular traits that were lost during the prior passage through an EMT (Brabletz, 2012) and enable reconstruction of hierarchical cell organizations similar to those present in the initial primary tumors.”
• The EMT-activator Zeb1 is a key factor for cell plasticity and promotes metastasis in pancreatic cancer (2017, neutral): “Scoring for CD31 and Gata6 was done according to staining intensity, with no (0), low (1), medium (2) and high (3) expression.”
• Implications of the Hybrid Epithelial/Mesenchymal Phenotype in Metastasis (2015, background): “At present, the exact mapping between EMT and stemness appears to be complex and context-dependent (6, 153), but with evidence suggesting that the major target to avoid tumor relapse and metastasis might be the CTCs in a hybrid E/M phenotype which have same degree of stemness (154).”
• Epithelial-mesenchymal transition spectrum quantification and its efficacy in deciphering survival and drug responses of cancer patients (2014, neutral): “…et al , 2013) — MDA-MB-231 breast cancer cells (Supplementary Fig S3) and may explain the limited correlation between generic EMT score and therapeutic resistance, as cancer stem cells may have an impact on tumour progression in breast (Sarrio et al , 2008) and colon (Brabletz, 2012) Epi tumours.”
• The RNA binding protein quaking regulates formation of circRNAs. (2015, neutral): “This has parallels in vivo as exemplified by the reversals of EMT that occur in some tissues during embryological development, while reversible plasticity is thought to play an important role in metastatic colonization (Brabletz, 2012; Nieto, 2013).”