FGFs, heparan sulfate and FGFRs: complex interactions essential for development.

By D. Ornitz. Bioessays, 2000

807 citations recorded by the source corpus.

Subfields: Cell Biology, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/45d4c9df12abb1b8301889a482ee8438a24ec250

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. Xinhua Lin
2. P. Marie
3. M. Mareel
4. O. De Wever
5. M. Tomic‐Canic
6. D. Ornitz

In Genetics

1. M. Mohammadi
2. Xinhua Lin
3. M. Kuro-o
4. M. Tomic‐Canic
5. P. Marie
6. M. Mareel
7. O. De Wever
8. D. Ornitz

In Molecular Biology

1. M. Mohammadi
2. M. Kuro-o
3. Xinhua Lin
4. O. De Wever
5. M. Mareel
6. D. Ornitz
7. P. Marie
8. M. Tomic‐Canic

Citations in the corpus

• Research resource: Comprehensive expression atlas of the fibroblast growth factor system in adult mouse. (2010, background): “Most of the 18 secreted FGFs interact with high affinity with heparan sulfate glycosaminoglycans (HSGAGs), which are either membrane anchored or present in the extracellular matrix (7).”
• Extracellular Matrix Communication and Turnover in Cardiac Physiology and Pathology (2015, neutral): “Among growth factors, transportation of fibroblast growth factors (FGFs) through proliferation, survival, migration and differentiation during development, growth, and in disease (222, 307, 326, 378, 496).”
• PERSPECTIVE ARTICLE: Growth factors and cytokines in wound healing (2008, background): “Essential for activation of the receptor, FGF must bind proteoglycans, such as heparin, that incorporates several ligands together in a web.(80) FGF-2, or basic FGF, is increased in the acute wound and plays a role in granulation tissue formation, reepithelialization, and tissue remodeling.”
• Role of tissue stroma in cancer cell invasion (2003, background): “Furthermore, biochemical and biological evidence points to a direct role for extracellular heparin/heparan sulphates in the formation of an active FGF/FGFR signalling complex [177].”
• FGF signaling pathways in endochondral and intramembranous bone development and human genetic disease. (2002, background): “Heparan chains, themselves, have unique tissue-specific modifications that are required for, and may actually regulate, functional ligand–receptor interactions (Rapraeger 1995; Guimond and Turnbull 1999; Ornitz 2000; Allen et al. 2001).”
• FGF signals guide migration of mesenchymal cells, control skeletal morphogenesis and regulate gastrulation during sea urchin development (2007, background): “The latter contains the invariant residues characteristic of the FGF core domain as well as several conserved residues implicated in binding of FGFs to Heparin and heparin sulphate proteoglycan (HSPG) (Bellosta et al., 2001; Ornitz, 2000; Ornitz and Itoh, 2001) (see Fig.”
• Functions of heparan sulfate proteoglycans in cell signaling during development (2004, background): “FGFs are among the best-studied HSPG-binding proteins (Ornitz, 2000), and play many important roles in regulating cell proliferation, migration and differentiation during development (Coumoul and Deng, 2003; Ornitz and Itoh, 2001).”