Electrical stimulation of excitable tissue: design of efficacious and safe protocols.

By Daniel R. Merrill, Marom Bikson, John Gordon Ralph Jefferys. Journal of Neuroscience Methods, 2005

2,040 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Cellular and Molecular Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/458cf8336500718cf1aed15f257549ef6fd7c6ba

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biomedical Engineering

In Cellular and Molecular Neuroscience

In Neurology

Citations in the corpus

A technical guide to tDCS, and related non-invasive brain stimulation tools (2015, background): “During tDCS, the metal or conductive rubber electrode is the site of electrochemical reactions (Merrill et al., 2005) and should not directly contact the skin.”
Progress Towards Biocompatible Intracortical Microelectrodes for Neural Interfacing Applications (2014, background): “Charge transfer reactions involving the exchange of charge between various carriers occur at the electrode–polymer and polymer–tissue interfaces [329].”
Biomimetic Tactile Sensor Array (2008, background): “the metal contacts and cause electrolysis of the electrolytic fluid [ 24 ].”
Low intensity transcranial electric stimulation: Safety, ethical, legal regulatory and application guidelines (2017, background): “In the case of tDCS, current across the interface is unidirectional, of course, and neural stimulation paradigms such as the above mentioned charge injection capacity (Cogan, 2008, Merrill et al., 2005) can therefore not be safely transferred directly to this type of stimulation.”
Physiological and modeling evidence for focal transcranial electrical brain stimulation in humans: A basis for high-definition tDCS (2013, methodology): “In contrast, a detailed modeling study of neuronal activation would require consideration of electrode capacitances and non-linearity (Merrill et al., 2005), and solving of the Laplace equation for each frequency (see Fourier-FEM approach, (Butson andMcIntyre, 2005)), followed by detailed biophysica”
Biomimetic sensory feedback through peripheral nerve stimulation improves dexterous use of a bionic hand (2019, background): “Furthermore, electrical stimulation of sensory afferents preferentially activates larger diameter fibers first (59), making USEA-evoked pain or temperature percepts uncommon.”
Safety of transcranial Direct Current Stimulation: Evidence Based Update 2016 (2016, background): “While metal inside the body has a high nominal conductivity, the metal is as an electron current carrier, whereas current carried by through the body (as produced by tDCS) is ionic; as such, a large electrode impedance is expected between the metal implant and the surrounding tissue making significa”
Revealing neuronal function through microelectrode array recordings (2015, positive): “The equivalent thermal noise can be calculated as follows: where k is the Boltzmann constant, T is the absolute temperature, Re ( Z e ) is the real part of the effective electrode impedance (see Section Neuron-electrode interface), and (cid:2) f is the noise bandwidth.”
Direct activation of sparse, distributed populations of cortical neurons by electrical microstimulation. (2009, background): “Second, axons have lower thresholds than cell bodies or dendrites (Stuart et al., 1997; Ranck, 1975; Tehovnik, 1996) in response to the effective current injection produced by extracellular stimulation (Durand, 2000; Rattay, 1999; Merrill et al., 2005).”
Noninvasive deep brain stimulation via temporally interfering electric fields (2017, positive): “The impact of electromagnetic stimulation on brain circuitry is an emergent function of the fields applied, the excitability properties of the neurons themselves, and the configuration of the neural network in which they are embedded (Merrill et al., 2005).”
A 2 $\mu\hbox{W}$ 100 nV/rtHz Chopper-Stabilized Instrumentation Amplifier for Chronic Measurement of Neural Field Potentials (2007, background): “The final constraint is the minimization of leakage currents through the electrodes; the input leakage must be well under 1 A to minimize electrode corrosion [10], [11].”
Temporal Interference Stimulation Enhances Neural Regeneration (2026, unknown): “A capacitor was added in line to both the stimulation and ground electrodes to remove the DC offset artifacts [ 166 ].”