SARS-CoV-2 vaccines in development

By F. Krammer. Nature, 2020

1,865 citations recorded by the source corpus.

Subfields: Infectious Diseases, Modeling and Simulation

View Paper: https://www.semanticscholar.org/paper/45847c0ed2d45266421afc473560f4c441385868

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Infectious Diseases

1. Alessandro Sette
2. Shane Crotty
3. Christian Drosten
4. F. Krammer
5. Jesse D. Bloom

Citations in the corpus

• Adaptive immunity to SARS-CoV-2 and COVID-19 (2021, neutral): “Adaptive immunity to SARS-CoV-2 infection Humans make SARS-CoV-2-specific antibodies, CD4 T cells, and CD8 T cells in response to SARS-CoV-2 infection (Grifoni et al., 2020; Krammer, 2020; Stephens and McElrath, 2020) (Figure 1).”
• Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection (2021, background): “Thus, COVID-19 vaccine development relies on immunological memory (1, 3).”
• Reduced neutralization of SARS-CoV-2 B.1.617 by vaccine and convalescent serum (2021, neutral): “Vaccines deliver S in a variety of different formats: RNA, viral vectors, recombinant protein, or in-activated virus (Krammer, 2020; Polack et al., 2020; Voysey et al., 2021; Baden et al., 2021; https://www.medscape.com/ viewarticle/944933).”
• The evolutionary dynamics of endemic human coronaviruses (2021, background): “Vaccines against COVID-19 provide a powerful mean to create herd immunity and control the pandemic, albeit long-term efficacy remains to be determined (Krammer 2020).”
• A human coronavirus evolves antigenically to escape antibody immunity (2020, background): “Second, many leading SARS-CoV-2 vaccines use new technologies such as mRNA-based delivery [78] that should make it easy to update the vaccine if there is antigenic evolution in spike.”
• Evidence for adaptive evolution in the receptor-binding domain of seasonal coronaviruses OC43 and 229e (2020, neutral): “In comparison, influenza H3N2 reinfects people roughly every 5 years ( Kucharski et al., 2015 ).”
• Evidence of escape of SARS-CoV-2 variant B.1.351 from natural and vaccine-induced sera (2021, methodology): “These have been developed using spike sequences derived from the early Wuhan strain and include recombinant protein, inactivated virus, RNA, and virally vectored platforms (Krammer, 2020).”