Features of systemic lupus erythematosus in Dnase1-deficient mice

By M. Napirei, H. Karsunky, B. Zevnik, H. Stephan, H. Mannherz, T. Möröy. Nature Genetics, 2000

834 citations recorded by the source corpus.

Subfields: Immunology, Radiology, Nuclear Medicine and Imaging, Rheumatology

View Paper: https://www.semanticscholar.org/paper/4511a636d11f309f7d5d6c168ff8c09fecb2bcb9

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In Immunology

In Radiology, Nuclear Medicine and Imaging

In Rheumatology

Citations in the corpus

Mutations in the gene encoding the 3′-5′ DNA exonuclease TREX1 cause Aicardi-Goutières syndrome at the AGS1 locus (2006, background): “Similarly, mice deficient in the lysosomal DNA endonucleases DNase I and II do not clear DNA derived from apoptotic cells, leading to an activation of innate immunit”
A blast from the past: clearance of apoptotic cells regulates immune responses (2002, neutral): “cgi?l=13419">DNase 1 , which degrades released chromati”
Origins, structures, and functions of circulating DNA in oncology (2016, background): “called damage-associated motif pattern (DAMP) [209, 213, 214].”
Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases (2008, background): “The importance of this pathway in preventing autoimmune responses is shown by the fact that mice deficient in DNase 1 develop a systemic lupus erythematosus (SLE)-like syndrom”
Trex1 prevents cell-intrinsic initiation of autoimmunity (2008, positive): “For example, deficiency for the extracellular DNase I causes a lupus-like syndrome in mice (Napirei et al., 2000), and DNase I mutations in humans are associated with lupus (Yasutomo et al., 2001).”
Type I interferons in host defense. (2006, positive): “Because there is little structural basis for discrimination between viral and host nucleic acids, it appears that pattern recognition in this case is aided by the compartmentalization of antiviral sensors and by activities of host nucleases that help eliminate self nucleic acids from the extracellul”
Apoptosis: controlled demolition at the cellular level (2008, background): “This suggests that apoptosis-associated DNA degradation helps to prevent the accumulation of DNA that, if released into the extracellular space, could provoke autoimmune response”
Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA (2006, background): “Mice that lack DNase I develop a lupus-like disease, and mutations in the gene encoding DNase I have been associated with the development of lupus in human”
STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors (2014, background): “Knockout mice lacking either of these DNases have been shown to be predisposed toward autoimmunity (Kawane et al., 2006; Napirei et al., 2000), indicating a particular importance for host control of extracellular DNA content in order to regulate endogenous immune responses.”