Global Mapping of the Yeast Genetic Interaction Network

By A. Tong, G. Lesage, Gary D. Bader, Huiming Ding, Hong Xu, Xiaofeng Xin, J. Young, G. Berriz, Renée L. Brost, Michael Chang and 40 more. Science, 2004

2,147 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/44ae92d5ff0fc3b00b3e2eba5282cd4cbca8ed76

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Citations in the corpus

The Importance of Bottlenecks in Protein Networks: Correlation with Gene Essentiality and Expression Dynamics (2007, methodology): “The genetic network data was downloaded from the GRID [49] and consists of several large-scale screens of genetic interactions [30, 50 ].”
Analysis of cell-based RNAi screens (2006, background): “Outlook Genome-wide RNAi experiments can be classified as follows: for screens, the goal is the identification of one or few new core components in a specifically assayed process followed by their in-depth genetic and biochemical characterization [17,38]; and for surveys, the aim is the systematic m”
Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex. (2005, positive): “The functional differences between these two complexes were shown by clustering of genetic interactions (Tong et al., 2001, 2004) and geneexpression profiles.”
Mapping pathways and phenotypes by systematic gene overexpression. (2006, methodology): “SGA allows introduction of marked alleles of a query gene into any appropriately marked yeast array through a series of replica pinning steps (Tong et al., 2004).”
The genetic landscape of a physical interaction (2018, background): “In budding yeast, this has been undertaken on a genomic scale, with the resulting network of interactions referred to as the ‘genetic landscape’ of a cell (Costanzo et al., 2010, 2016; Tong et al., 2004).”
Comparative Genomics in Eukaryotes (2005, background): “It was found earlier that genetic interactions (Tong et al., 2004) on their own are only marginally useful for predicting direct interactions, but shared genetic interactions do indicate involvement in similar pathways (Ozier et al.”
Computer vision for high content screening (2016, background): “Their screen combined HCS with synthetic genetic arrays (Tong et al ., 2001) and discovered (cid:2) 122 additional genes involved in spindle function that were not previously identified in a colony fitness based genetic interaction screen (Tong et al ., 2004).”