IL-10 Is Required for Regulatory T Cells to Mediate Tolerance to Alloantigens In Vivo1

By Masaki Hara, C. I. Kingsley, M. Niimi, S. Read, S. Turvey, A. Bushell, P. Morris, F. Powrie, K. Wood. Journal of Immunology, 2001

873 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/44a9d79ba3a1ac2b1aafeaf1a04a4819f857345d

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Citations in the corpus

Interleukin-10 Therapy—Review of a New Approach (2003, background): “In fact, IL-10 inhibits ischemia/reperfusion injury (Deng et al., 2001), prolongs allograft survival (Feng et al., 1999; Zuo et al., 2001), and is essential for the action of regulatory T cells mediating tolerance at least in some transplant models (Hara et al., 2001).”
Cutting Edge: Regulatory T Cells from Lung Cancer Patients Directly Inhibit Autologous T Cell Proliferation1 (2002, background): “(23) have shown that CD4 CD25 T cells suppress MLRs, but only when the alloantigen was presented by the indirect and not the direct pathway of allorecognition.”
IL-10-Secreting Regulatory T Cells Do Not Express Foxp3 but Have Comparable Regulatory Function to Naturally Occurring CD4+CD25+ Regulatory T Cells 1 (2004, background): “IL-10 produced by CD4 CD25 TReg is involved in protection from induced colitis (20) and allograft rejection (21), in the control of naive T cell proliferation in vivo in immunocompromised mice (22) and in the”
Regulatory T Cells Induced by 1α,25-Dihydroxyvitamin D3 and Mycophenolate Mofetil Treatment Mediate Transplantation Tolerance1 (2001, background): “More recently, tolerance to alloantigens in vivo has been found to be maintained by CD4 cells expressing CD25 or CD45RB low (6).”
Regulatory T cells in cancer. (2006, background): “Additionally, IL10 and TGFβ although rarely expressed in vitro might have functional importance for Treg cells in vivo, particularly in context of disease.(29,30) Major topics of current research are the characterization of Treg cell defects in autoimmune diseases and their role in infectious diseas”
CD25+CD4+ Regulatory T Cells Prevent Graft Rejection: CTLA-4- and IL-10-Dependent Immunoregulation of Alloresponses1 (2002, background): “The explanation for this difference seen between these data and ours is not apparent at present; however, in a previous study (14) we have also shown that CD45RBCD4 T cells from naive animals were unable to regulate rejection.”