Mutations in the gene encoding the 3′-5′ DNA exonuclease TREX1 are associated with systemic lupus erythematosus

By M. Lee-Kirsch, Maolian Gong, Dipanjan Chowdhury, L. Senenko, K. Engel, Young-Ae Lee, U. D. Silva, S. Bailey, T. Witte, T. Vyse and 14 more. Nature Genetics, 2007

667 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Rheumatology

View Paper: https://www.semanticscholar.org/paper/443992a86650d6f5f9c909d94b91ccce78822316

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Shizuo Akira
2. Taro Kawai
3. R. Medzhitov
4. O. Takeuchi
5. Daniel B. Stetson
6. Zhijian J. Chen
7. G. Barber
8. T. Heidmann

In Molecular Biology

1. Shizuo Akira
2. Taro Kawai
3. O. Takeuchi
4. R. Medzhitov
5. Daniel B. Stetson
6. G. Barber
7. T. Heidmann
8. J. S. Ko

In Rheumatology

1. Shizuo Akira
2. Daniel B. Stetson
3. R. Medzhitov
4. Haig H. Kazazian
5. J. Goodier

Citations in the corpus

• Trex1 prevents cell-intrinsic initiation of autoimmunity (2008, positive): “Trex1 contains a predicted transmembrane helix at its C terminus , suggesting that it may be an integral membrane protein of the ER (Lee-Kirsch et al., 2007b).”
• The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors (2010, background): “Mutations in the gene encoding the repair exonuclease TREX1 are found in Aicardi-Goutieres syndrome, which is characterized by a fatal encephalopathy associated with greater production of type I interfero”
• Activation of STING requires palmitoylation at the Golgi (2016, positive): “Mice lacking DNase II or DNase III (Trex1) die during embryonic development or within 10 weeks of birth, respectively, with inflammation-related phenotypes.”
• Pattern recognition receptors and inflammation. (2010, background): “Similarly, deficiency in DNase I, a major DNase present in serum, results in the generation of SLE-like autoimmune disease in mice; a mutation in DNase I has been identified in human SLE patients (Lee-Kirsch et al., 2007).”