Dysregulation of PRMT1 and PRMT6, Type I arginine methyltransferases, is involved in various types of human cancers

By Masanori Yoshimatsu, G. Toyokawa, S. Hayami, M. Unoki, Tatsuhiko Tsunoda, Helen I. Field, John D. Kelly, D. Neal, Yoshihiko Maehara, B. Ponder and 2 more. 2011

318 citations recorded by the source corpus.

Subfields: Molecular Biology

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Citations in the corpus

RB1 methylation by SMYD2 enhances cell cycle progression through an increase of RB1 phosphorylation. (2012, methodology): “The siRNA sequences are described in Table W2. siRNA duplexes (final concentration, 100 nM) were transfected into bladder and lung cancer cell lines with Lipofectamine 2000 (Life Technologies, Carlsbad, CA) [17,22].”
PRMT6 increases cytoplasmic localization of p21CDKN1A in cancer cells through arginine methylation and makes more resistant to cytotoxic agents (2015, background): “Given that the induction of p21-mediated growth suppressive functions is considered as a critical mechanism for several anticancer agents such as HDAC inhibitors [36, 37] and that PRMT6 is significantly overexpressed in various types of cancer [15], PRMT6 is likely to be a promising anti-cancer drug”
WHSC1 Promotes Oncogenesis through Regulation of NIMA-Related Kinase-7 in Squamous Cell Carcinoma of the Head and Neck (2014, methodology): “The number of viable cells was measured using the Cell Counting Kit-8 (Dojindo) at days 6 to 8 (24, 25).”
Enhanced expression of EHMT2 is involved in the proliferation of cancer cells through negative regulation of SIAH1. (2011, methodology): “[27] Yoshimatsu M, Toyokawa G, Hayami S, Unoki M, Tsunoda T, Field HI, Kelly JD, Neal DE, Maehara Y, Ponder BA, et al.”
Enhanced HSP70 lysine methylation promotes proliferation of cancer cells through activation of Aurora kinase B (2012, unknown): “IB: HA (AURKB) HA–AURKB – – + – + – FLAG–AURKB-[1-200] FLAG–AURKB-[201-344]”
PRMT1 promotes mitosis of cancer cells through arginine methylation of INCENP (2015, methodology): “Indeed, transactivation of PRMT1 was found in various types of cancer [16, 28-31], and inhibition of PRMT1 significantly suppresses growth of cancer cells [16, 30, 31].”
Minichromosome Maintenance Protein 7 is a potential therapeutic target in human cancer and a novel prognostic marker of non-small cell lung cancer (2011, methodology): “We previously reported that PRMT6, a type I arginine methytransferase, is involved in human carcinogenesis [27].”
Novel prognostic marker PRMT1 regulates cell growth via downregulation of CDKN1A in HCC (2017, background): “PRMT1 is a histone arginine methyltransferase that mainly catalyzes H3R4me and me2 to activate gene expression [13, 14].”
The histone methyltransferase Wolf–Hirschhorn syndrome candidate 1‐like 1 (WHSC1L1) is involved in human carcinogenesis (2013, methodology): “The statistical procedure for micaroarray analysis was described preciously (Hayami et al., 2010, 2011; Cho et al., 2011a; Yoshimatsu et al., 2011).”
Late Cornified Envelope Group I, a Novel Target of p53, Regulates PRMT5 Activity (2014, background): “Current progress of molecular medicine revealed that the enzymes relevant to histonemethylation play critical roles in human carcinogenesis [28,35–45].”
Histone lysine methyltransferase Wolf-Hirschhorn syndrome candidate 1 is involved in human carcinogenesis through regulation of the Wnt pathway. (2011, background): “[32] Yoshimatsu M, Toyokawa G, Hayami S, Unoki M, Tsunoda T, Field HI, Kelly JD, Neal DE, Maehara Y, Ponder BA, et al.”
The Histone Demethylase JMJD2B Plays an Essential Role in Human Carcinogenesis through Positive Regulation of Cyclin-Dependent Kinase 6 (2011, methodology): “Microarray hybridization and statistical analysis for the clarification of downstream genes Microarray analysis to identify downstream genes were done as described previously (21).”
SMYD3-mediated lysine methylation in the PH domain is critical for activation of AKT1 (2016, unknown): “Small interfering RNA (siRNA) oligonucleotide duplexes were purchased from Sigma-Aldrich for targeting the human SMYD3 transcript. siEGFP was used as a control siRNA [47–52].”