WHSC1 Promotes Oncogenesis through Regulation of NIMA-Related Kinase-7 in Squamous Cell Carcinoma of the Head and Neck
By V. Saloura, Hyun-soo Cho, K. Kiyotani, Houda Alachkar, Zhixiang Zuo, Makoto Nakakido, Tatsuhiko Tsunoda, T. Seiwert, M. Lingen, J. Licht and 2 more. 2014
91 citations recorded by the source corpus.
Subfields: Genetics, Molecular Biology
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In Molecular Biology
- Ryuji Hamamoto
- Yusuke Nakamura
- Takehiro Suzuki
- N. Dohmae
- Lianhua Piao
- Syuzo Kaneko
- Masaaki Komatsu
- Ken Asada
Citations in the corpus
- WHSC1 monomethylates histone H1 and induces stem-cell like features in squamous cell carcinoma of the head and neck (2020, background): “We recently showed that WHSC1 is significantly and frequently overexpressed in tumors of locoregionally advanced SCCHN, its overexpression was associated with poor differentiation and was necessary for the survival of SCCHN cells partially through transcriptional upregulation of the cell cycle relat”
- Epigenetics Analysis and Integrated Analysis of Multiomics Data, Including Epigenetic Data, Using Artificial Intelligence in the Era of Precision Medicine (2019, background): “phosphorylation and sumoylation and non-coding RNAs [15,20,21].”
- WHSC1L1 drives cell cycle progression through transcriptional regulation of CDC6 and CDK2 in squamous cell carcinoma of the head and neck (2016, unknown): “Given that WHSC1L1 is recurrently amplified in SCCHN and that few studies have explored the role of PKMTs in SCCHN [8], we aimed to evaluate its potential function as an oncogenic force in this disease, and to elucidate relevant mechanisms of its oncogenic activity.”
- SMYD3-mediated lysine methylation in the PH domain is critical for activation of AKT1 (2016, unknown): “Following this, cells were washed 4 times with PBS and mounting medium with 4’,6’-diamidine-2’-phenylindole dihydrochloride (DAPI, VECTASHIELD ® , Vector Laboratories) was added on each well [53].”
- SUV39H2 methylates and stabilizes LSD1 by inhibiting polyubiquitination in human cancer cells (2015, background): “Many reports have indicated that dysregulation of protein lysine methyltransferases and protein lysine demethylases has important roles in human tumorigenesis [32-37].”