Synaptic scaling mediated by glial TNF-α

By D. Stellwagen, R. Malenka. Nature, 2006

1,549 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/43ba535257f285ea0bee0f1d39719530ca46435b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. Gina G. Turrigiano
2. M. Sofroniew
3. D. Feldman
4. Niraj S. Desai
5. Maiken Nedergaard
6. A. Watt
7. Alexei Verkhratsky
8. C. Eroglu

In Cognitive Neuroscience

1. Gina G. Turrigiano
2. Niraj S. Desai
3. A. Watt
4. D. Feldman
5. Qianli Liao
6. Joel Z. Leibo
7. Tomaso A. Poggio
8. R. Malenka

In Neurology

1. Gina G. Turrigiano
2. M. Sofroniew
3. J. Burda
4. Maiken Nedergaard
5. Alexei Verkhratsky
6. B. Barres
7. C. Eroglu
8. R. Yirmiya

Citations in the corpus

• Homeostatic synaptic plasticity: local and global mechanisms for stabilizing neuronal function. (2012, background): “In this collection on the synapse, I will focus on synaptic mechanisms that are likely to contribute to network homeostasis.”
• Debris clearance by microglia: an essential link between degeneration and regeneration (2008, background): “For example, TNF- has been shown to protect neurons against Ab mediated toxicity (Barger, 1995) under pathological conditions and the absence of glial derived TNF- revealed a role in homoeostatic synaptic scaling under physiological conditions (Stellwagen and Malenka, 2006).”
• The mystery and magic of glia: a perspective on their roles in health and disease. (2008, background): “TNFa even plays a role in controlling normal function and plasticity of neural circuits in vitro and in vivo (Stellwagen and Malenka, 2006; Kaneko et al., 2008).”
• Immune modulation of learning, memory, neural plasticity and neurogenesis. (2011, background): “…synaptic scaling following prolonged inhibition of neuronal activity, via secretion of the pro-inflammatory cytokine TNFa (Kaneko et al., 2008; Stellwagen and Malenka, 2006), a known synaptic strength enhancer, which increases the surface expression of AMPA glutamatergic receptors (Beattie et…”
• How Important Is Weight Symmetry in Backpropagation? (2015, methodology): “, Synaptic Scaling) in the brain [16, 17, 18].”
• Synaptic Mechanisms for Plasticity in Neocortex (2009, background): “Recent work suggests that glial cells, which detect mean local network activity, trigger one form of synaptic scaling in hippocampus and visual cortex by secreting the cytokine tumor-necrosis factor-α (TNF-α) (Stellwagen & Malenka 2006, Kaneko et al. 2008b).”