CORUM: the comprehensive resource of mammalian protein complexes

By Andreas Ruepp, Barbara Brauner, I. Dunger, Goar Frishman, Corinna Montrone, Michaela Stransky, Brigitte Waegele, Thorsten Schmidt, Octave Noubibou Doudieu, V. Stümpflen and 1 more. Nucleic Acids Res., 2007

460 citations recorded by the source corpus.

Protein complexes are key molecular entities that integrate multiple gene products to perform cellular functions. The CORUM (http://mips.gsf.de/genre/proj/corum/index.html) database is a collection of experimentally verified mammalian protein complexes. Information is manually derived by critical reading of the scientific literature from expert annotators. Information about protein complexes includes protein complex names, subunits, literature references as well as the function of the complexes. For functional annotation, we use the FunCat catalogue that enables to organize the protein complex space into biologically meaningful subsets. The database contains more than 1750 protein complexes that are built from 2400 different genes, thus representing 12% of the protein-coding genes in human. A web-based system is available to query, view and download the data. CORUM provides a comprehensive dataset of protein complexes for discoveries in systems biology, analyses of protein networks and protein complex-associated diseases. Comparable to the MIPS reference dataset of protein complexes from yeast, CORUM intends to serve as a reference for mammalian protein complexes.

Subfields: Molecular Biology

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Citations in the corpus

SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways (2013, methodology): “To identify complexes regulated by SIRT5 and Lys succinylation, we performed protein complex enrichment analysis with the 30, June 27, 2013 ª2013 Elsevier Inc. 923 manually curated CORUM core complex database (Ruepp et al., 2008) for mammalian proteins.”
Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool (2013, methodology): “The pathways category includes gene-set libraries from well-known pathway databases such as WikiPathways [25], KEGG [26], BioCarta, and Reactome [27] as well as five gene-set libraries we created from our own resources: kinase enrichment analysis (KEA) [28] for kinases and their known substrates, pr”
1D and 2D annotation enrichment: a statistical method integrating quantitative proteomics with complementary high-throughput data (2012, background): “For human data the Corum database [27] is a well curated repository of protein complexes.”
CORUM: the comprehensive resource of mammalian protein complexes—2009 (2007, methodology): “Data from yeast have shown that at least 45% of the gene complement function as subunits in protein complexes (14).”
Network-based in silico drug efficacy screening (2016, background): “Wetookthehuman protein–protein interaction (PPI) network compiled by Menche et al. 12 that contained experimentally documented human physical interactions from TRANSFAC 38 , IntAct 39 , MINT 40 , BioGRID 41 , HPRD 42 , KEGG 43 , BIGG 44 , CORUM 45 , PhosphoSitePlus 46 and a large scale signalling ne”
The harmonizome: a collection of processed datasets gathered to serve and mine knowledge about genes and proteins (2016, background): “Wikipathways Pathways (90) CORUM Protein Complexes (91, 92)”
Hypergraphs and Cellular Networks (2009, unknown): “Finally, we want to mention a hypergraph analysis of a mammalian protein complex hypergraph acquired from the CORUM database [43].”
CORUM: the comprehensive resource of mammalian protein complexes—2019 (2018, background): “In order to provide a high-quality resource of information on mammalian protein complexes, we generated the comprehensive resource of mammalian protein complexes (CORUM) with 1750 complexes in the first release (10).”
Negatome 2.0: a database of non-interacting proteins derived by literature mining, manual annotation and protein structure analysis (2013, methodology): “The results obtained by text mining were manually verified by examining the original publications, analogously to the annotation of PPIs and protein complexes previously performed by our group (21,22).”
Systematic discovery of Xist RNA binding proteins (2015, background): “%) of all proteins identified were within two degrees of separations from the core spliceosome (Figure 2B) or the direct binding proteins of U1 (Figure S2A) (Pomeranz Krummel et al., 2009; Ruepp et al., 2008; Stark et al., 2001), suggesting that ChIRP-MS yields the immediate and most relevant protei”
ConsensusPathDB: toward a more complete picture of cell biology (2010, methodology): “The newly integrated data include complex protein interactions from Corum (4), large-scale protein”