Mitochondria as sensors and regulators of calcium signalling

By R. Rizzuto, D. D. Stefani, A. Raffaello, C. Mammucari. Nature reviews. Molecular cell biology, 2012

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How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Mitochondria in the regulation of innate and adaptive immunity (2015, positive): “The best example of this is the rapid sequestration of calcium into the mitochondrial matrix in response to elevations in cytosolic calcium (Rizzuto et al., 2012).”
13 reasons why the brain is susceptible to oxidative stress (2018, background): “Beyond oxidative phosphorylation, mitochondria are essential signalling hubs regulating a veritable plethora of essential processes, from Ca homeostasis, Fe-S cluster synthesis to cell fate [55,108,109].”
Calcium and ROS: A mutual interplay (2015, background): “The driving force for calcium uptake by the MCU was found to be the steep negative membrane potential established by the respiratory chain [124].”
Initiation and perpetuation of NLRP3 inflammasome activation and assembly (2015, background): “Cyclosporine A (CsA) strongly inhibits NLRP3 inflammasome activation, but this inhibition may be independent of its effects on cyclophilin D (CypD)-mediated MPT (105, 106, 127).”
Mitochondrial dysfunction in pathophysiology of heart failure (2018, background): “org Volume 128 Number 9 September 2018 Whether mitochondria serve as a major Ca2+ sink is also controversial (12, 98).”