The cholinergic anti-inflammatory pathway.

By Valentin A. Pavlov, Kevin J. Tracey. Brain, behavior, and immunity, 2005

599 citations recorded by the source corpus.

Subfields: Molecular Biology, Neurology, Sensory Systems

View Paper: https://www.semanticscholar.org/paper/4331367cce6a9560d5a781c158bdb4b1dcf4e999

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Citations in the corpus

Fly Cell Atlas: a single-nucleus transcriptomic atlas of the adult fruit fly (2022, background): “Finally, expression of acetylcholine receptors was specific for a subset of hemocytes, relating to the cholinergic anti-inflammatory pathway as described in humans and mice (26).”
Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression (2009, unknown): “In addition, in vitro studies have demonstrated that stimulation of both alpha- and beta-adrenergic receptors can activate inflammatory signaling pathways, including NF-κB(87).”
Cytokines sing the blues: inflammation and the pathogenesis of depression. (2006, background): “Vagal withdrawal in response to stress might also promote inflammation, given the evidence that vagal activity inhibits NFkB activation (and the release of TNF-α from macrophages) via cholinergic signaling through the α-7 subunit of the nicotinic acetylcholine receptor [77].”
Inflammatory processes in Alzheimer's disease. (2007, unknown): “Thus, neurons can serve as source of complement, COX-2-derived prostanoids (Davis and Laroche, 2003; Pavlov and Tracey, 2005; Rozemuller et al., 1989b; Simard et al., 2006; Natarajan and Bright, 2002; Moore et al., 2005), and several cytokines including IL-1β, IL-6, and TNF-α (Botchkina et al.,…”
Psychological Stress in Childhood and Susceptibility to the Chronic Diseases of Aging: Moving Towards a Model of Behavioral and Biological Mechanisms (2011, background): “Haensel et al. (2008); Marsland et al. (2007); Pavlov and Tracey (2005) - Oxytocin concentrations are lower in individuals who have experienced maltreatment relative to controls.”
Acetylcholine beyond neurons: the non‐neuronal cholinergic system in humans (2008, background): “Macrophages, mononuclear cells a7 Anti-inflammatory effects, release of proinflammatory cytokines k Shytle et al. (2004); Pavlov and Tracey (2005) T cells a7 Interaction with TRC, Cain m Razani-Boroujerdi et al. (2007) B cells a7 Regulation of antibody production Kawashima et al. (2007) Mucosal…”
The effects of acute psychological stress on circulating and stimulated inflammatory markers: A systematic review and meta-analysis (2017, background): “The PNS acts through acetylcholine receptors in immune cells to down-regulate pro-inflammatory cytokine production (Borovikova et al., 2000; Marsland, Gianaros, Prather, Manuck, 2007) and circulating markers of inflammation (Sloan et al., 2007; Pavlov & Tracey, 2005).”
Cytokines and their relationship to the symptoms and outcome of cancer (2008, background): “Although often overlooked, neuronal pathways and hormones (such as cortisol and adrenaline”
Gut feelings: the emerging biology of gut–brain communication (2011, background): “Vagal modulation of macrophage activation through nicotinic acetylcholine receptors has been reported as part of a vago–vagal anti-inflammatory refle”
The Effect of Antidepressant Medication Treatment on Serum Levels of Inflammatory Cytokines: A Meta-Analysis (2011, unknown): “An elevated level of circulating inflammatory cytokines may occur because of a dysfunction in the brain’s anti-inflammatory mechanisms, which include the hypothalamic–pituitary–adrenal axis, the efferent vagus (Bierhaus et al, 2003; Pavlov and Tracey, 2005; Shaked et al, 2009), and noradrenergic inn”