The role of iron and reactive oxygen species in cell death.

By Scott J. Dixon, Brent R. Stockwell. Nature Chemical Biology, 2014

2,119 citations recorded by the source corpus.

Subfields: Hematology, Nutrition and Dietetics, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/432c30470b50e8c1a729abad1204793bfc368061

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Hematology

1. C. López‐Otín
2. Scott J. Dixon
3. Brent R. Stockwell
4. Edward A. Miao
5. G. Núñez
6. M. Karin
7. Scott W. Lowe
8. D. Tang

In Nutrition and Dietetics

1. D. Tang
2. Brent R. Stockwell
3. R. Kang
4. Scott J. Dixon
5. M. Conrad
6. W. Yang
7. J. Cao
8. Guido Kroemer

In Pulmonary and Respiratory Medicine

1. Brent R. Stockwell
2. D. Tang
3. R. Kang
4. Guido Kroemer
5. Scott J. Dixon
6. M. Conrad
7. D. Klionsky
8. W. Yang

Citations in the corpus

• Role of pyroptosis in inflammation and cancer (2022, background): “In addition to pyroptosis, iron can trigger several types of cell death, such as ferroptosis, ironinduced necroptosis and apoptosis, all of which are consequences of complex signaling pathways in cells [175, 179].”
• Essential versus accessory aspects of cell death: recommendations of the NCCD 2015 (2014, background): “Both the pharmacologic and genetic inhibition of CYPD fail to prevent ferroptosis as triggered by erastin, a small molecule that is selectively lethal for cancer cells expressing oncogenic variants of Harvey rat sarcoma viral oncogene homolog (HRAS).(246,248) This suggests that ferroptosis and MPT-d”
• Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 (2018, background): “Moreover, the toxicity of high extracellular glutamate may depend (at least in part) on the activation of ferroptosis through cysteine imbalance [534, 538, 552].”
• ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases (2016, background): “ROS is integral in the development of physiopathologic events like mitochondrial death signaling [86] and autophagy [87], besides inflammation and infection [55, 88], in which they impart immunological changes.”
• The Development of the Concept of Ferroptosis (2018, neutral): “by iron chelators, knockdown of the iron transporter transferrin or its receptor, or the lack of iron in serum [25,109,114,122,123], as well as”
• Nrf2 inhibition reverses the resistance of cisplatin-resistant head and neck cancer cells to artesunate-induced ferroptosis (2016, background): “Ferroptosis causes cell death through the ironmediated accumulation of lipid ROS and interference of cellular integrity and membrane fluidity and permeability [38].”
• Ferroptosis, a new form of cell death, and its relationships with tumourous diseases (2016, background): “In the central nervous system (CNS), the neurotoxicity of glutamate is oxidative iron-dependent [40, 41].”
• Ferroptosis in cancer therapy: a novel approach to reversing drug resistance (2022, background): “The generation of ROS initiates lipid peroxidation and eventually leads to ferroptosis [23].”